Literature DB >> 7805858

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase.

G C Brown1, C E Cooper.   

Abstract

Nitric oxide (NO) reversibly inhibited oxygen consumption of brain synaptosomes. Inhibition was reversible, occurred at the level of cytochrome oxidase, and was apparently competitive with oxygen, with half-inhibition by 270 nM NO at oxygen concentrations around 145 microM and by 60 nM at around 30 microM O2. Isolated cytochrome oxidase was inhibited by similar levels of NO. These levels of NO are within the measured physiological and pathological range for a number of tissues and conditions, suggesting that NO inhibition of cytochrome oxidase and the competition with oxygen may occur in vivo.

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Year:  1994        PMID： 7805858     DOI： 10.1016/0014-5793(94)01290-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  240 in total

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5.  Mechanisms of the interaction of nitroxyl with mitochondria.

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Journal:  Neurochem Res       Date:  2004-03       Impact factor: 3.996

8.  Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals.

Authors:  Enzo Nisoli; Sestina Falcone; Cristina Tonello; Valeria Cozzi; Letizia Palomba; Mara Fiorani; Addolorata Pisconti; Silvia Brunelli; Annalisa Cardile; Maura Francolini; Orazio Cantoni; Michele O Carruba; Salvador Moncada; Emilio Clementi
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-15       Impact factor: 11.205

Review 9.  Review: Mitochondria and disease progression in multiple sclerosis.

Authors:  D Mahad; H Lassmann; D Turnbull
Journal:  Neuropathol Appl Neurobiol       Date:  2008-12       Impact factor: 8.090

10.  Nitric oxide consumption through lipid peroxidation in brain cell suspensions and homogenates.

Authors:  Robert G Keynes; Charmaine H Griffiths; Catherine Hall; John Garthwaite
Journal:  Biochem J       Date:  2005-05-01       Impact factor: 3.857
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