Literature DB >> 7805831

Identification of defensin binding to C1 complement.

A V Panyutich1, O Szold, P H Poon, Y Tseng, T Ganz.   

Abstract

In human serum we found strong defensin binding to the complexes of activated C1 complement (C1) and C1 inhibitor (C1i). Purified C1q, activated C1 tetramer (r2s2) and C1i did not bind defensin. When r2s2 was dissociated by EDTA, only the activated C1s (C1s) bound defensin. Binding of defensins to C1 complement represents a newly recognized bridge between the complement- and phagocyte-mediated host defenses, and a potential mechanism for protecting infected tissue from cytotoxic injury by defensin.

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Year:  1994        PMID： 7805831     DOI： 10.1016/0014-5793(94)01261-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial.

Authors:  K A Brogden; M Ackermann; K M Huttner
Journal:  Antimicrob Agents Chemother       Date:  1997-07       Impact factor: 5.191

2.  Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations.

Authors:  J Shi; G Zhang; H Wu; C Ross; F Blecha; T Ganz
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

3.  Susceptibility of Chlamydia trachomatis to protegrins and defensins.

Authors:  B Yasin; S S Harwig; R I Lehrer; E A Wagar
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

4.  Through the looking glass, mechanistic insights from enantiomeric human defensins.

Authors:  Gang Wei; Erik de Leeuw; Marzena Pazgier; Weirong Yuan; Guozhang Zou; Jianfeng Wang; Bryan Ericksen; Wei-Yue Lu; Robert I Lehrer; Wuyuan Lu
Journal:  J Biol Chem       Date:  2009-07-29       Impact factor: 5.157

Review 5.  Targeting and inactivation of bacterial toxins by human defensins.

Authors:  Elena Kudryashova; Stephanie M Seveau; Dmitri S Kudryashov
Journal:  Biol Chem       Date:  2017-09-26       Impact factor: 4.700

6.  Modulation of the complement system by human beta-defensin 2.

Authors:  Satyanarayan Bhat; Yau-Hau Song; Carl Lawyer; Stephen M Milner
Journal:  J Burns Wounds       Date:  2007-01-10

7.  Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study.

Authors:  Jakob Albrethsen; Rikke Bøgebo; Steen Gammeltoft; Jesper Olsen; Benny Winther; Hans Raskov
Journal:  BMC Cancer       Date:  2005-01-19       Impact factor: 4.430

Review 8.  The overlapping roles of antimicrobial peptides and complement in recruitment and activation of tumor-associated inflammatory cells.

Authors:  Izzat A M Al-Rayahi; Raghad H H Sanyi
Journal:  Front Immunol       Date:  2015-01-22       Impact factor: 7.561

9.  Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator.

Authors:  Ilia A Krenev; Ekaterina S Umnyakova; Igor E Eliseev; Yaroslav A Dubrovskii; Nikolay P Gorbunov; Vladislav A Pozolotin; Alexei S Komlev; Pavel V Panteleev; Sergey V Balandin; Tatiana V Ovchinnikova; Olga V Shamova; Mikhail N Berlov
Journal:  Mar Drugs       Date:  2020-12-10       Impact factor: 5.118

Review 10.  Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?

Authors:  Lars Steinstraesser; Ursula M Kraneburg; Tobias Hirsch; Marco Kesting; Hans-Ulrich Steinau; Frank Jacobsen; Sammy Al-Benna
Journal:  Int J Mol Sci       Date:  2009-09-09       Impact factor: 6.208
  10 in total

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