Literature DB >> 7805789

Serum amyloid P component-induced cell death in primary cultures of rat cerebral cortex.

Z Urbányi1, V Lakics, S L Erdö.   

Abstract

The influence of serum amyloid P component (SAP) on the survival of rat cerebrocortical cultures was tested. Cytotoxic cell death was examined on 8-9-day-old cell cultures by phase contrast microscopy and quantified by the measurement of lactate dehydrogenase (LDH) leakage. SAP (16-48 nM) evoked a concentration-dependent cell death within 24 h exposure. Our results suggest that SAP, as a constituent of cerebral amyloid deposits, may play a role in the pathomechanism of Alzheimer's disease.

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Year:  1994        PMID： 7805789     DOI： 10.1016/0926-6917(94)90016-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.

Authors:  Simon E Kolstoe; Basil H Ridha; Vittorio Bellotti; Nan Wang; Carol V Robinson; Sebastian J Crutch; Geoffrey Keir; Riitta Kukkastenvehmas; J Ruth Gallimore; Winston L Hutchinson; Philip N Hawkins; Stephen P Wood; Martin N Rossor; Mark B Pepys
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-16       Impact factor: 11.205

2.  Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease.

Authors:  Anna Csiszar; Zsuzsanna Tucsek; Peter Toth; Danuta Sosnowska; Tripti Gautam; Akos Koller; Ferenc Deak; William E Sonntag; Zoltan Ungvari
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-08-16       Impact factor: 4.733

3.  Efflux transport of serum amyloid P component at the blood-brain barrier.

Authors:  Szilvia Veszelka; Judit Laszy; Tamás Pázmány; László Németh; Izabella Obál; László Fábián; Gábor Szabó; Csongor S Abrahám; Mária A Deli; Zoltán Urbányi
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2013-11-21

Review 4.  Pattern recognition by pentraxins.

Authors:  Alok Agrawal; Prem Prakash Singh; Barbara Bottazzi; Cecilia Garlanda; Alberto Mantovani
Journal:  Adv Exp Med Biol       Date:  2009       Impact factor: 2.622

5.  Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection.

Authors:  Goutam Patra; Bibhuti Saha; Sumi Mukhopadhyay
Journal:  Sci Rep       Date:  2021-01-12       Impact factor: 4.379

Review 6.  Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology.

Authors:  M Mahafuzur Rahman; Christofer Lendel
Journal:  Mol Neurodegener       Date:  2021-08-28       Impact factor: 14.195

7.  Dementia in the older population is associated with neocortex content of serum amyloid P component.

Authors:  Stephan Ellmerich; Graham W Taylor; Connor D Richardson; Thais Minett; Amand Floriaan Schmidt; Carol Brayne; Fiona E Matthews; Paul G Ince; Stephen B Wharton; Mark B Pepys
Journal:  Brain Commun       Date:  2021-10-09

8.  Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo.

Authors:  Raya Al-Shawi; Glenys A Tennent; David J Millar; Angela Richard-Londt; Sebastian Brandner; David J Werring; J Paul Simons; Mark B Pepys
Journal:  Open Biol       Date:  2016-02       Impact factor: 6.411

Review 9.  The Pentraxins 1975-2018: Serendipity, Diagnostics and Drugs.

Authors:  Mark B Pepys
Journal:  Front Immunol       Date:  2018-10-16       Impact factor: 7.561
  9 in total

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