Literature DB >> 7805455

Ionizing radiation-induced IL-1 alpha, IL-6 and GM-CSF production by human lung cancer cells.

J S Zhang1, S Nakatsugawa, O Niwa, G Z Ju, S Z Liu.   

Abstract

A cell line derived from human lung cancer (AOI) was employed in the present study. A panel of cytokines were quantified by ELISA technique following cellular exposure to X-irradiation. Tremendous increase in the levels of both IL-1 alpha and IL-6 were observed, GM-CSF was also detected. A comparison of time kinetics of IL-1 alpha and IL-6 production was made with that of cell cycle progression which was determined by FCM BrdU/DNA bivariate analysis. No cell cycle specific changes were found. The biological implication of radiation-induced cytokine production was discussed.

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Year:  1994        PMID： 7805455

Source DB:  PubMed          Journal:  Chin Med J (Engl)        ISSN： 0366-6999            Impact factor:   2.628


  14 in total

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