[The correlation between occurrence of intracranial germ cell tumors and p53 tumor suppressor gene mutations].

Using PCR-SSCP molecular biological techniques and sequencing analysis, an investigation on intracranial germ cell tumors for a correlation between the p53 tumor suppressor gene mutations and the occurrence of these tumors was performed. The results were as follows: 1. The p53 gene mutations were closely related with the development of intracranial germ cell tumors; 2. Among the germ cell tumors, different types of tumors had different p53 tumor gene mutations.