Literature DB >> 7804839

Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases.

D A DeWitt1, P L Richey, D Praprotnik, J Silver, G Perry.   

Abstract

Previously, we showed three differentially sulfated forms of chondroitin sulfate proteoglycans (CSPG) associated with senile plaques, astrocytes and neurofibrillary tangles in Alzheimer's disease. Here, monoclonal antibodies were used to demonstrate CSPGs in other neurodegenerative diseases. CSPGs were found associated with inclusions of Parkinson's, diffuse Lewy body, Pick's diseases, and progressive supranuclear palsy. Reacting astrocytes in each of these neurodegenerative diseases and Huntington's disease showed immunoreactivity for CSPG. CSPG distribution in a variety of neurodegenerative diseases suggests that similar mechanisms may be involved in the accumulation of proteoglycans in a number of filamentous inclusions.

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Year:  1994        PMID： 7804839     DOI： 10.1016/0006-8993(94)91386-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.

Authors:  M A Smith; P L Harris; L M Sayre; G Perry
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

Review 2.  Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?

Authors:  K E Rhodes; J W Fawcett
Journal:  J Anat       Date:  2004-01       Impact factor: 2.610

Review 3.  The Lewy body in Parkinson's disease and related neurodegenerative disorders.

Authors:  Koichi Wakabayashi; Kunikazu Tanji; Saori Odagiri; Yasuo Miki; Fumiaki Mori; Hitoshi Takahashi
Journal:  Mol Neurobiol       Date:  2012-05-24       Impact factor: 5.590

4.  Inhibitors of myelination: ECM changes, CSPGs and PTPs.

Authors:  Danielle E Harlow; Wendy B Macklin
Journal:  Exp Neurol       Date:  2013-11-04       Impact factor: 5.330

5.  Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils.

Authors:  Surabhi Mehra; Dhiman Ghosh; Rakesh Kumar; Mrityunjoy Mondal; Laxmikant G Gadhe; Subhadeep Das; Arunagiri Anoop; Narendra N Jha; Reeba S Jacob; Debdeep Chatterjee; Soumik Ray; Nitu Singh; Ashutosh Kumar; Samir K Maji
Journal:  J Biol Chem       Date:  2018-06-29       Impact factor: 5.157

6.  Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease.

Authors:  Joshua D Crapser; Joseph Ochaba; Neelakshi Soni; Jack C Reidling; Leslie M Thompson; Kim N Green
Journal:  Brain       Date:  2020-01-01       Impact factor: 13.501

Review 7.  "Targeting astrocytes in CNS injury and disease: A translational research approach".

Authors:  Angela R Filous; Jerry Silver
Journal:  Prog Neurobiol       Date:  2016-03-26       Impact factor: 11.685

8.  Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders.

Authors:  Rocco Adiutori; Fabiola Puentes; Michael Bremang; Vittoria Lombardi; Irene Zubiri; Emanuela Leoni; Johan Aarum; Denise Sheer; Simon McArthur; Ian Pike; Andrea Malaspina
Journal:  Brain Commun       Date:  2021-07-09

9.  Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type.

Authors:  Elisabet Ihse; Hodaka Yamakado; Xander M van Wijk; Roger Lawrence; Jeffrey D Esko; Eliezer Masliah
Journal:  Sci Rep       Date:  2017-08-21       Impact factor: 4.379

10.  Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses.

Authors:  Jessica Mitlöhner; Rahul Kaushik; Hartmut Niekisch; Armand Blondiaux; Christine E Gee; Max F K Happel; Eckart Gundelfinger; Alexander Dityatev; Renato Frischknecht; Constanze Seidenbecher
Journal:  Cells       Date:  2020-01-21       Impact factor: 6.600
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