Literature DB >> 7803524

Diminished cerebral metabolic response to motor stimulation in schizophrenics: a PET study.

W Guenther1, J D Brodie, E J Bartlett, S L Dewey, F A Henn, N D Volkow, K Alper, A Wolkin, R Cancro, A P Wolf.   

Abstract

Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia under all scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.

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Year:  1994        PMID： 7803524     DOI： 10.1007/bf02191884

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Clin Neurosci        ISSN： 0940-1334            Impact factor:   5.270


  51 in total

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Authors:  B Pakkenberg
Journal:  Acta Neurol Scand Suppl       Date:  1992

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Journal:  Science       Date:  1988-07-22       Impact factor: 47.728

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Journal:  Ann Neurol       Date:  1988-02       Impact factor: 10.422

4.  A synthesis of 2-deoxy-D-[1-11C]glucose for regional metabolic studies: concise communication.

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Journal:  J Nucl Med       Date:  1981-09       Impact factor: 10.057

Review 5.  Speculation on the meaning of cerebral metabolic hypofrontality in schizophrenia.

Authors:  D R Weinberger; K F Berman
Journal:  Schizophr Bull       Date:  1988       Impact factor: 9.306

6.  Use of 2-deoxy-D[1-11C]glucose for the determination of local cerebral glucose metabolism in humans: variation within and between subjects.

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Journal:  J Cereb Blood Flow Metab       Date:  1982-09       Impact factor: 6.200

7.  Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging.

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Journal:  Biol Psychiatry       Date:  1991-03-15       Impact factor: 13.382

8.  Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia.

Authors:  H Szechtman; C Nahmias; E S Garnett; G Firnau; G M Brown; R D Kaplan; J M Cleghorn
Journal:  Arch Gen Psychiatry       Date:  1988-06

9.  Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness.

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10.  Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism.

Authors:  D R Weinberger; K F Berman; B P Illowsky
Journal:  Arch Gen Psychiatry       Date:  1988-07
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  6 in total

1.  Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia.

Authors:  P M Thompson; C Vidal; J N Giedd; P Gochman; J Blumenthal; R Nicolson; A W Toga; J L Rapoport
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

2.  Functional EEG mapping and SPECT in detoxified male alcoholics.

Authors:  W Günther; N Müller; P Knesewitsch; C Haag; W Trapp; J P Banquet; C Stieg; K R Alper
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1997       Impact factor: 5.270

3.  Psychomotor disturbances in psychiatric patients as a possible basis for new attempts at differential diagnosis and therapy. Part VI. Evaluation of psychomotor training programs in schizophrenic patients.

Authors:  W Günther; P Streck; N Müller; G R Mair; E Kalischek; W Bender; R Günther
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1995       Impact factor: 5.270

4.  Functional magnetic resonance imaging of motor cortex activation in schizophrenia.

Authors:  Hyo Jong Lee; Adrian Preda; Judith M Ford; Daniel H Mathalon; David B Keator; Theo G M van Erp; Jessica A Turner; Steven G Potkin
Journal:  J Korean Med Sci       Date:  2015-04-15       Impact factor: 2.153

5.  Association between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia.

Authors:  Pinhong Chen; Enmao Ye; Xiao Jin; Yuyang Zhu; Lubin Wang
Journal:  Sci Rep       Date:  2019-02-27       Impact factor: 4.379

Review 6.  A Hierarchical Generative Framework of Language Processing: Linking Language Perception, Interpretation, and Production Abnormalities in Schizophrenia.

Authors:  Meredith Brown; Gina R Kuperberg
Journal:  Front Hum Neurosci       Date:  2015-11-27       Impact factor: 3.169
  6 in total

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