Literature DB >> 7803521

Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells.

L Korutla1, R Kumar.   

Abstract

We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells. The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors. The observed early effects of Curcumin were mediated via a cellular mechanism(s), and preceded the period when inhibition of cell growth occurred.

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Year:  1994        PMID： 7803521     DOI： 10.1016/0167-4889(94)90299-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  21 in total

Review 1.  Colorectal cancer: chemopreventive role of curcumin and resveratrol.

Authors:  Vaishali B Patel; Sabeena Misra; Bhaumik B Patel; Adhip P N Majumdar
Journal:  Nutr Cancer       Date:  2010       Impact factor: 2.900

2.  Enhancement of phototoxicity of curcumin in human oral cancer cells using silica nanoparticles as delivery vehicle.

Authors:  Surya Prakash Singh; Mrinalini Sharma; Pradeep Kumar Gupta
Journal:  Lasers Med Sci       Date:  2013-06-27       Impact factor: 3.161

3.  Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling.

Authors:  Hiroyasu Sakai; Ken Sato; Fumiaki Sato; Yuki Kai; Kazutaka Mandokoro; Kenjiro Matsumoto; Shinichi Kato; Tetsuro Yumoto; Minoru Narita; Yoshihiko Chiba
Journal:  Inflamm Res       Date:  2017-04-12       Impact factor: 4.575

4.  Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase.

Authors:  Madesh Belakavadi; Bharathi P Salimath
Journal:  Mol Cell Biochem       Date:  2005-05       Impact factor: 3.396

5.  Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells.

Authors:  Xiuzhen Han; Baoshan Xu; Christopher S Beevers; Yoshinobu Odaka; Long Chen; Lei Liu; Yan Luo; Hongyu Zhou; Wenxing Chen; Tao Shen; Shile Huang
Journal:  Carcinogenesis       Date:  2012-01-31       Impact factor: 4.944

6.  Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells.

Authors:  Qing-Yong Chen; Jian-Guo Shi; Qing-Hua Yao; De-Min Jiao; Yan-Yi Wang; Hui-Zhen Hu; Yu-Quan Wu; Jia Song; Jie Yan; Li-Jun Wu
Journal:  Mol Cell Biochem       Date:  2011-08-28       Impact factor: 3.396

7.  Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells.

Authors:  Matthew Miller; Shenglin Chen; Jeffrey Woodliff; Sanjay Kansra
Journal:  Endocrinology       Date:  2008-05-01       Impact factor: 4.736

8.  Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression.

Authors:  Mohiuddin M Taher; Guido Lammering; Chad Hershey; Kristoffer Valerie
Journal:  Mol Cell Biochem       Date:  2003-12       Impact factor: 3.396

9.  Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines.

Authors:  Tiffany J Somers-Edgar; Sebastien Taurin; Lesley Larsen; Anupama Chandramouli; Mark A Nelson; Rhonda J Rosengren
Journal:  Invest New Drugs       Date:  2009-10-09       Impact factor: 3.850

10.  Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells.

Authors:  Dong Kyun Kim; Song Ja Kim; Shin Sung Kang; Eun Jung Jin
Journal:  Exp Mol Med       Date:  2009-09-30       Impact factor: 8.718
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