| Literature DB >> 7803503 |
J J Yohn1, C Smith, T Stevens, J G Morelli, L R Shurnas, S J Walchak, T A Hoffman, K K Kelley, A Escobedo-Morse, M Yanagisawa.
Abstract
We investigated endothelin-1 (ET-1) receptor expression on normal human keratinocytes (HK). We show that HK express the ETB receptor isoform and respond to ET-1 with a 2.7-fold increase in intracellular free calcium. HK did not respond to ET-1 with increased proliferation; however, 30 nM ET-1 caused a 51.7% decrease in ET-1 accumulation in HK-conditioned medium. We propose that HK ET-1 receptors function in autocrine regulation of ET-1 secretion.Entities:
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Year: 1994 PMID： 7803503 DOI： 10.1016/0167-4889(94)90282-8
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002