Literature DB >> 7802649

NGF stimulates differentiation of osteoblastic MC3T3-E1 cells.

M Yada1, K Yamaguchi, T Tsuji.   

Abstract

The activities of NGF on induction of IL-6, ALP and collagen were studied in cultured osteoblastic cells, MC3T3-E1. Treatment of the cells with NGF induced IL-6 production in a dose dependent manner and enhanced ALP activity and collagen biosynthesis without affecting cell proliferation. Cyclo-oxygenase was activated in NGF-treated cells and prostaglandinE2 was detected as a major metabolite from arachidonic acid. Since prostaglandinE2 is an enhancer of ALP activity and collagen biosynthesis in MC3T3-E1 and was found to induce IL-6 production in this study, it is possible that NGF works on MC3T3-E1 cells through the mediation by endogenous prostaglandinE2.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7802649     DOI： 10.1006/bbrc.1994.2791

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

Review 1.  Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions.

Authors:  J M García-Castellano; P Díaz-Herrera; J A Morcuende
Journal:  Iowa Orthop J       Date:  2000

Review 2.  Application of chemical factors for acceleration of consolidation phase of the distraction osteogenesis: a scoping review.

Authors:  Sadra Mohaghegh; Fatemeh Alirezaei; Nima Ahmadi; Farnaz Kouhestani; Saeed Reza Motamedian
Journal:  Oral Maxillofac Surg       Date:  2022-07-19

3.  Nerve growth factor beta(NGF beta) delivery via a collagen/hydroxyapatite (Col/HAp) composite and its effects on new bone ingrowth.

Authors:  A Letic-Gavrilovic; A Piattelli; K Abe
Journal:  J Mater Sci Mater Med       Date:  2003-02       Impact factor: 3.896

4.  [Local injection of exogenous nerve growth factor improves early bone maturation of implants].

Authors:  Yang Yao; Yu Du; Xia Gu; Meng-Kai Guang; Bo Huang; Ping Gong
Journal:  Hua Xi Kou Qiang Yi Xue Za Zhi       Date:  2018-04-01

Review 5.  No pain, no gain? The effects of pain-promoting neuropeptides and neurotrophins on fracture healing.

Authors:  Seungyup Sun; Nicklaus H Diggins; Zachary J Gunderson; Jill C Fehrenbacher; Fletcher A White; Melissa A Kacena
Journal:  Bone       Date:  2019-11-09       Impact factor: 4.398

6.  The TrkA agonist gambogic amide augments skeletal adaptation to mechanical loading.

Authors:  Gabriella Fioravanti; Phuong Q Hua; Ryan E Tomlinson
Journal:  Bone       Date:  2021-03-11       Impact factor: 4.626

7.  Locally Produced BDNF Promotes Sclerotic Change in Alveolar Bone after Nerve Injury.

Authors:  Hiroko Ida-Yonemochi; Yurie Yamada; Hiroyuki Yoshikawa; Kenji Seo
Journal:  PLoS One       Date:  2017-01-10       Impact factor: 3.240

8.  Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells.

Authors:  Xinxin Zhang; Xiaorui Jiang; Shan Jiang; Xiyu Cai; Shengji Yu; Guoxian Pei
Journal:  Stem Cell Res Ther       Date:  2021-07-07       Impact factor: 6.832

9.  Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc.

Authors:  Devina Purmessur; Anthony J Freemont; Judith A Hoyland
Journal:  Arthritis Res Ther       Date:  2008-08-27       Impact factor: 5.156

10.  Periosteum Metabolism and Nerve Fiber Positioning Depend on Interactions between Osteoblasts and Peripheral Innervation in Rat Mandible.

Authors:  Cédric Mauprivez; Caroline Bataille; Brigitte Baroukh; Annie Llorens; Julie Lesieur; Pierre J Marie; Jean-Louis Saffar; Martin Biosse Duplan; Marc Cherruau
Journal:  PLoS One       Date:  2015-10-28       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.