PURPOSE: To test a combination treatment of ibuprofen and methylprednisolone for pain and swelling. METHODS: The efficacy of 32 mg methylprednisolone on pain and swelling when given 12 hours before and after surgery in combination with 400 mg ibuprofen three times a day given immediately on the day of the operation and on the two subsequent days following removal of impacted third molars was investigated in a placebo-controlled, intraindividual double-blind study. RESULTS: After use of ibuprofen/methylprednisolone, ultrasonic examination showed a reduction in swelling of 56% (P < .001) compared with the placebo group; measurement with a tape measure showed a 58% (P < .001) reduction in swelling. The visual analog scale showed a reduction of 67.7% in postoperative pain in comparison with placebo. CONCLUSION: The combination of ibuprofen and methylprednisolone has good analgesic and antiinflammatory action.
RCT Entities:
PURPOSE: To test a combination treatment of ibuprofen and methylprednisolone for pain and swelling. METHODS: The efficacy of 32 mg methylprednisolone on pain and swelling when given 12 hours before and after surgery in combination with 400 mg ibuprofen three times a day given immediately on the day of the operation and on the two subsequent days following removal of impacted third molars was investigated in a placebo-controlled, intraindividual double-blind study. RESULTS: After use of ibuprofen/methylprednisolone, ultrasonic examination showed a reduction in swelling of 56% (P < .001) compared with the placebo group; measurement with a tape measure showed a 58% (P < .001) reduction in swelling. The visual analog scale showed a reduction of 67.7% in postoperative pain in comparison with placebo. CONCLUSION: The combination of ibuprofen and methylprednisolone has good analgesic and antiinflammatory action.