Literature DB >> 7798968

Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors.

T Schmeller1, M Sauerwein, F Sporer, M Wink, W E Müller.   

Abstract

Fourteen quinolizidine alkaloids, isolated from Lupinus albus, L. mutabilis, and Anagyris foetida, were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. Of the compounds tested, the alpha-pyridones, N-methylcytisine and cytisine, showed the highest affinities at the nicotinic receptor, while several quinolizidine alkaloid types were especially active at the muscarinic receptor.

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Year:  1994        PMID： 7798968     DOI： 10.1021/np50111a026

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

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Review 2.  Counting on natural products for drug design.

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3.  Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors.

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4.  The biogeographical distribution of duncecap larkspur (Delphinium occidentale) chemotypes and their potential toxicity.

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5.  Sophora alopecuroides L. var. alopecuroides alleviates morphine withdrawal syndrome in mice: involvement of alkaloid fraction and matrine.

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Review 6.  Modes of Action of Herbal Medicines and Plant Secondary Metabolites.

Authors:  Michael Wink
Journal:  Medicines (Basel)       Date:  2015-09-08

7.  Lupin (Lupinus spp.) seeds exert anthelmintic activity associated with their alkaloid content.

Authors:  O Dubois; C Allanic; C L Charvet; F Guégnard; H Février; I Théry-Koné; J Cortet; C Koch; F Bouvier; T Fassier; D Marcon; J B Magnin-Robert; N Peineau; E Courtot; C Huau; A Meynadier; C Enguehard-Gueiffier; C Neveu; L Boudesocque-Delaye; G Sallé
Journal:  Sci Rep       Date:  2019-06-21       Impact factor: 4.379

Review 8.  Fragment-based screening with natural products for novel anti-parasitic disease drug discovery.

Authors:  Miaomiao Liu; Ronald J Quinn
Journal:  Expert Opin Drug Discov       Date:  2019-09-12       Impact factor: 6.098

9.  Lupanine Improves Glucose Homeostasis by Influencing KATP Channels and Insulin Gene Expression.

Authors:  Mats Wiedemann; Carmen M Gurrola-Díaz; Belinda Vargas-Guerrero; Michael Wink; Pedro M García-López; Martina Düfer
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  9 in total

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