Literature DB >> 7798672

Catalase expression, katG, and MIC of isoniazid for Mycobacterium tuberculosis isolates from São Paulo, Brazil.

L Ferrazoli1, M Palaci, M A Telles, S Y Ueki, A Kritski, L R Marques, O C Ferreira, L W Riley.   

Abstract

The MIC of isoniazid, peroxidase-catalase expression, and the presence of the katG gene for 102 Mycobacterium tuberculosis isolates from patients in São Paulo were compared. Fifty-three isoniazid-resistant and 49 isoniazid-sensitive isolates were analyzed by polymerase chain reaction (PCR) for the presence of katG sequences. All isoniazid-sensitive and 43 (81%) isoniazid-resistant isolates expressed catalase (P = .001). None of isoniazid-sensitive and 4 (7%) of 53 isoniazid-resistant isolates lacked katG sequences. Among 6 isolates with MICs > 50 micrograms/mL, 5 (83%) did not express catalase and 2 lacked katG sequences; only 1 had complete gene deletion shown by Southern blot analysis. These findings indicate a correlation between loss of catalase and isoniazid resistance among highly resistant isolates, but these isolates were a small proportion of resistant clinical M. tuberculosis isolates from São Paulo.

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Year:  1995        PMID： 7798672     DOI： 10.1093/infdis/171.1.237

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  6 in total

1.  Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.

Authors:  Rosilene Fressatti Cardoso; Robert C Cooksey; Glenn P Morlock; Patricia Barco; Leticia Cecon; Francisco Forestiero; Clarice Q F Leite; Daisy N Sato; Maria de Lourdes Shikama; Elsa M Mamizuka; Rosario D C Hirata; Mario H Hirata
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

2.  Evaluation of mycobacteria growth indicator tube for recovery and drug susceptibility testing of Mycobacterium tuberculosis isolates from respiratory specimens.

Authors:  M Palaci; S Y Ueki; D N Sato; M A Da Silva Telles; M Curcio; E A Silva
Journal:  J Clin Microbiol       Date:  1996-03       Impact factor: 5.948

3.  katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.

Authors:  H J Marttila; H Soini; P Huovinen; M K Viljanen
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

Review 4.  Role of oxidants in microbial pathophysiology.

Authors:  R A Miller; B E Britigan
Journal:  Clin Microbiol Rev       Date:  1997-01       Impact factor: 26.132

5.  Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare.

Authors:  G S Pretorius; P D van Helden; F Sirgel; K D Eisenach; T C Victor
Journal:  Antimicrob Agents Chemother       Date:  1995-10       Impact factor: 5.191

Review 6.  Multidrug-resistant tuberculosis.

Authors:  Antônio Carlos Moreira Lemos; Eliana Dias Matos
Journal:  Braz J Infect Dis       Date:  2013-03-09       Impact factor: 3.257
  6 in total

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