Literature DB >> 7796919

Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit.

H Sakura1, C Bond, M Warren-Perry, S Horsley, L Kearney, S Tucker, J Adelman, R Turner, F M Ashcroft.   

Abstract

The ATP-sensitive K-channel plays a central role in insulin release from pancreatic beta-cells. We report here the cloning of the gene (KCNJ6) encoding a putative subunit of a human ATP-sensitive K-channel expressed in brain and beta-cells, and characterisation of its exon-intron structure. Screening of a somatic cell mapping panel and fluorescent in situ hybridization place the gene on chromosome 21 (21q22.1-22.2). Analysis of single-stranded conformational polymorphisms revealed the presence of two silent polymorphisms (Pro-149: CCG-CCA and Asp-328: GAC-GAT) with similar frequencies in normal and non-insulin-dependent diabetic patients.

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Year:  1995        PMID： 7796919     DOI： 10.1016/0014-5793(95)00498-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  A human pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of the genomic structure and genetic variations in Japanese NIDDM patients.

Authors:  Y Tanizawa; A Matsubara; K Ueda; H Katagiri; A Kuwano; J Ferrer; M A Permutt; Y Oka
Journal:  Diabetologia       Date:  1996-04       Impact factor: 10.122

2.  In vivo and in vitro functional characterization of Andersen's syndrome mutations.

Authors:  Saïd Bendahhou; Emmanuel Fournier; Damien Sternberg; Guillaume Bassez; Alain Furby; Carole Sereni; Matthew R Donaldson; Marie-Madeleine Larroque; Bertrand Fontaine; Jacques Barhanin
Journal:  J Physiol       Date:  2005-04-14       Impact factor: 5.182

3.  Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.

Authors:  H Sakura; N Wat; V Horton; H Millns; R C Turner; F M Ashcroft
Journal:  Diabetologia       Date:  1996-10       Impact factor: 10.122

4.  New mechanisms for sulfonylurea control of insulin secretion.

Authors:  L S Satin
Journal:  Endocrine       Date:  1996-06       Impact factor: 3.633

Review 5.  Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice.

Authors:  Maria Sara Remedi; Colin G Nichols
Journal:  Cell Metab       Date:  2009-12       Impact factor: 27.287

6.  Two novel cSNPs of weaver gene in Chinese indigenous goat and their associations with milk yield.

Authors:  Zhuanjian Li; Zhongqi Chen; Xianyong Lan; Liang Ma; Yujiao Qu; Yanli Liu; Mijie Li; Ping Wang; Fei Li; Hong Chen
Journal:  Mol Biol Rep       Date:  2010-01       Impact factor: 2.316

7.  Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism.

Authors:  Kingsley Osuala; Candice N Baker; Ha-Long Nguyen; Celines Martinez; David Weinshenker; Steven N Ebert
Journal:  Physiol Genomics       Date:  2012-08-21       Impact factor: 3.107

8.  Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery.

Authors:  Daisuke Nishizawa; Makoto Nagashima; Ryoji Katoh; Yasuo Satoh; Megumi Tagami; Shinya Kasai; Yasukazu Ogai; Wenhua Han; Junko Hasegawa; Naohito Shimoyama; Ichiro Sora; Masakazu Hayashida; Kazutaka Ikeda
Journal:  PLoS One       Date:  2009-09-16       Impact factor: 3.240

Review 9.  Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

Authors:  Patrik Rorsman; Frances M Ashcroft
Journal:  Physiol Rev       Date:  2018-01-01       Impact factor: 37.312

10.  A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.

Authors:  Evadnie Rampersaud; Guolian Kang; Lance E Palmer; Sara R Rashkin; Shuoguo Wang; Wenjian Bi; Nicole M Alberts; Doralina Anghelescu; Martha Barton; Kirby Birch; Nidal Boulos; Amanda M Brandow; Russell John Brooke; Ti-Cheng Chang; Wenan Chen; Yong Cheng; Juan Ding; John Easton; Jason R Hodges; Celeste K Kanne; Shawn Levy; Heather Mulder; Ashwin P Patel; Latika Puri; Celeste Rosencrance; Michael Rusch; Yadav Sapkota; Edgar Sioson; Akshay Sharma; Xing Tang; Andrew Thrasher; Winfred Wang; Yu Yao; Yutaka Yasui; Donald Yergeau; Jane S Hankins; Vivien A Sheehan; James R Downing; Jeremie H Estepp; Jinghui Zhang; Michael DeBaun; Gang Wu; Mitchell J Weiss
Journal:  Blood Adv       Date:  2021-07-27
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