Literature DB >> 7796907

Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein.

T Falk1, W Meyerhof, B J Corrette, J Schäfer, C K Bauer, J R Schwarz, D Richter.   

Abstract

In GH3/B6 cells at least two different inward K+ currents are observed that are regulated by thyrotropin-releasing hormone and somatostatin, respectively. Using a polymerase chain reaction based approach a cDNA was isolated and functionally expressed in human embryonic kidney cells that encodes an inward rectifier K+ channel, rIRK3, with a predicted molecular mass of 49.7 kDa. Corresponding transcripts of 2.6 kb have been detected in rat brain, pituitary and GH3/B6 cells. In situ hybridization revealed that rIRK3 mRNA is distributed throughout the brain and occurs predominantly in the piriform cortex, indusium griseum, supraoptic nucleus, facial nucleus and cerebellar Purkinje cells.

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Year:  1995        PMID： 7796907     DOI： 10.1016/0014-5793(95)00527-g

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

Authors:  Regina Preisig-Müller; Günter Schlichthörl; Tobias Goerge; Steffen Heinen; Andrea Brüggemann; Sindhu Rajan; Christian Derst; Rüdiger W Veh; Jürgen Daut
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

2.  Assignment of the murine inwardly rectifying potassium channel IRK3 gene (Kcnj4) to the mouse chromosome 15.

Authors:  K Morishige; T Takumi; N Takahashi; H Koyama; H Kurachi; A Miyake; Y Murata; N G Copeland; D J Gilbert; N A Jenkins; Y Kurachi
Journal:  Mamm Genome       Date:  1997-09       Impact factor: 2.957

3.  Neurochemical and electrophysiological characteristics of rat striatal neurons in primary culture.

Authors:  Torsten Falk; Shiling Zhang; Emilie L Erbe; Scott J Sherman
Journal:  J Comp Neurol       Date:  2006-01-10       Impact factor: 3.215

4.  IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain.

Authors:  C Karschin; E Dissmann; W Stühmer; A Karschin
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

5.  Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family.

Authors:  R B Nehring; E Wischmeyer; F Döring; R W Veh; M Sheng; A Karschin
Journal:  J Neurosci       Date:  2000-01-01       Impact factor: 6.167

6.  Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.

Authors:  C Töpert; F Döring; E Wischmeyer; C Karschin; J Brockhaus; K Ballanyi; C Derst; A Karschin
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

7.  Characterization of 5-HT-sensitive potassium conductances in neonatal rat facial motoneurones in vitro.

Authors:  P M Larkman; J S Kelly
Journal:  J Physiol       Date:  1998-04-01       Impact factor: 5.182

8.  GABAergic activation of an inwardly rectifying K+ current in mouse cerebellar Purkinje cells.

Authors:  Toshihide Tabata; Shigeki Haruki; Hisako Nakayama; Masanobu Kano
Journal:  J Physiol       Date:  2005-01-06       Impact factor: 5.182
  8 in total

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