DESIGN:Placebo for 3 months, followed by 30 mg/day zinc gluconate in identical capsules. SETTING:Diabetic out patients clinic at the University Hospital, Grenoble. SUBJECTS:Diabetic patients cared for type I diabetes mellitus. 22 patients began the study, 4 dropped out. 10 patients suffered of an early retinopathy, 8 patients had no retinopathy. INTERVENTIONS: In this order: T0 biological measurements, 3 months placebo treatment, T1 biological measurements, 3 months zinc gluconate treatment, T2 biological measurements. Plasma Zn, Cu, Se, thiobarbituric acid reactants and antioxidant enzymes were measured [plasma and red glutathione peroxidase (Se-GPx), red cell superoxide dismutase (Cu-Zn-SOD)]. RESULTS:Lower plasma zinc level in the two groups. An increase in zinc level was observed and was more important in diabetic patients with no retinopathy (P = 0.05). The thiobarbituric acid reactants were above the reference values in all the patients, and were decreased at T2 (P < 0.05). Increase of GPx activity after zinc supplementation in patients with retinopathy. CONCLUSIONS:Zinc deficiency in insulin-dependent diabetic patients is corrected by a zinc supplementation. Moreover this supplementation decreases lipid peroxidation. The effects of zinc are different in diabetic patients with or without retinopathy. The increase in Se-GPx activity observed in patients with retinopathy could be linked to the protective effect of zinc on the protein itself.
RCT Entities:
DESIGN: Placebo for 3 months, followed by 30 mg/day zinc gluconate in identical capsules. SETTING:Diabetic out patients clinic at the University Hospital, Grenoble. SUBJECTS:Diabeticpatients cared for type I diabetes mellitus. 22 patients began the study, 4 dropped out. 10 patients suffered of an early retinopathy, 8 patients had no retinopathy. INTERVENTIONS: In this order: T0 biological measurements, 3 months placebo treatment, T1 biological measurements, 3 months zinc gluconate treatment, T2 biological measurements. Plasma Zn, Cu, Se, thiobarbituric acid reactants and antioxidant enzymes were measured [plasma and red glutathione peroxidase (Se-GPx), red cell superoxide dismutase (Cu-Zn-SOD)]. RESULTS: Lower plasma zinc level in the two groups. An increase in zinc level was observed and was more important in diabeticpatients with no retinopathy (P = 0.05). The thiobarbituric acid reactants were above the reference values in all the patients, and were decreased at T2 (P < 0.05). Increase of GPx activity after zinc supplementation in patients with retinopathy. CONCLUSIONS: Zinc deficiency in insulin-dependent diabeticpatients is corrected by a zinc supplementation. Moreover this supplementation decreases lipid peroxidation. The effects of zinc are different in diabeticpatients with or without retinopathy. The increase in Se-GPx activity observed in patients with retinopathy could be linked to the protective effect of zinc on the protein itself.
Authors: Arce Domingo-Relloso; Maria Grau-Perez; Laisa Briongos-Figuero; Jose L Gomez-Ariza; Tamara Garcia-Barrera; Antonio Dueñas-Laita; Jennifer F Bobb; F Javier Chaves; Marianthi-Anna Kioumourtzoglou; Ana Navas-Acien; Josep Redon-Mas; Juan C Martin-Escudero; Maria Tellez-Plaza Journal: Int J Epidemiol Date: 2019-12-01 Impact factor: 7.196