C Hollis1. 1. Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London.
Abstract
BACKGROUND: The study tests the hypothesis that juvenile-onset schizophrenia is associated with premorbid developmental impairments. It was predicted that the pattern of developmental impairments would vary with age of onset and with gender. METHOD: A case-control design was used to examine developmental impairments in 61 consecutive juvenile-onset (age 7-17) referrals with ICD-9 schizophrenia; 61 non-psychotic psychiatric controls were matched on age and gender. Cases and controls were divided into childhood-onset (age 7-13) and adolescent-onset (age 14-17). RESULTS: The schizophrenic cases had a significantly higher risk of premorbid social (chi 2 = 9.1, P < 0.005), motor (chi 2 = 9.1, P < 0.005) and language impairments (chi 2 = 10.1, P < 0.005). Specific impairments of language production and comprehension were associated with childhood-onset schizophrenia and were independent of gender. CONCLUSIONS: Juvenile-onset schizophrenia is associated with a range of developmental antecedents. There may be a specific link between cases with a very early onset and an impairment in the processes underlying the development of language.
BACKGROUND: The study tests the hypothesis that juvenile-onset schizophrenia is associated with premorbid developmental impairments. It was predicted that the pattern of developmental impairments would vary with age of onset and with gender. METHOD: A case-control design was used to examine developmental impairments in 61 consecutive juvenile-onset (age 7-17) referrals with ICD-9 schizophrenia; 61 non-psychotic psychiatric controls were matched on age and gender. Cases and controls were divided into childhood-onset (age 7-13) and adolescent-onset (age 14-17). RESULTS: The schizophrenic cases had a significantly higher risk of premorbid social (chi 2 = 9.1, P < 0.005), motor (chi 2 = 9.1, P < 0.005) and language impairments (chi 2 = 10.1, P < 0.005). Specific impairments of language production and comprehension were associated with childhood-onset schizophrenia and were independent of gender. CONCLUSIONS: Juvenile-onset schizophrenia is associated with a range of developmental antecedents. There may be a specific link between cases with a very early onset and an impairment in the processes underlying the development of language.
Authors: Jay N Giedd; Rhoshel K Lenroot; Philip Shaw; Francois Lalonde; Mark Celano; Samantha White; Julia Tossell; Anjene Addington; Nitin Gogtay Journal: Novartis Found Symp Date: 2008
Authors: Frederike Schirmbeck; Alexander Georgi; Jana Strohmaier; Christine Schmael; Katja V Boesshenz; Thomas W Mühleisen; Stefan Herms; Per Hoffmann; Rami Abou Jamra; Johannes Schumacher; Wolfgang Maier; Peter Propping; Markus M Nöthen; Sven Cichon; Marcella Rietschel; Thomas G Schulze Journal: J Autism Dev Disord Date: 2008-05-13
Authors: Anna E Ordóñez; Frances F Loeb; Xueping Zhou; Lorie Shora; Rebecca A Berman; Diane D Broadnax; Peter Gochman; Siyuan Liu; Judith L Rapoport Journal: J Am Acad Child Adolesc Psychiatry Date: 2016-07-01 Impact factor: 8.829