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Literature DB >> 7794717

Tubulointerstitial nephritis and uveitis: an immunological disorder?

R Birnbacher¹, E Balzar, C Aufricht, S Schmaldienst, W Woloszczuk, E Förster.

Abstract

A 14-year-old boy with tubulointerstitial nephritis and uveitis (TINU syndrome) is described. Nephropathy improved without systemic cortisone treatment, whereas uveitis relapsed and was treated with topical steroids. Blood cell immunological analysis and serum analysis revealed signs of cytotoxic T-cell, macrophage and granulocyte activation, which declined as the clinical symptoms improved. This may be interpreted as an indication of their significance as markers in the pathogenesis of this syndrome or as part of a microbial-triggered immune response.

Entities: Chemical Disease Species

Mesh：

Year: 1995 PMID： 7794717 DOI： 10.1007/bf00860744

Source DB: PubMed Journal: Pediatr Nephrol ISSN： 0931-041X Impact factor: 3.714

23 in total

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Journal: J Immunol Date: 1987-11-01 Impact factor: 5.422

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Journal: J Leukoc Biol Date: 1991-05 Impact factor: 4.962

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Journal: Immunol Today Date: 1988-04

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Authors: T Uchiyama; D L Nelson; T A Fleisher; T A Waldmann
Journal: J Immunol Date: 1981-04 Impact factor: 5.422

5. A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy.

Authors: K Hirano; Y Tomino; H Mikami; K Ota; Y Aikawa; I Shirato; H Koide
Journal: Am J Nephrol Date: 1989 Impact factor: 3.754

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Authors: M Burnier; P Jaeger; M Campiche; J P Wauters
Journal: Am J Nephrol Date: 1986 Impact factor: 3.754

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Authors: T I Steinman; P Silva
Journal: Am J Med Date: 1984-07 Impact factor: 4.965

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Authors: D Ellis; W A Fried; E J Yunis; E B Blau
Journal: Pediatrics Date: 1981-06 Impact factor: 7.124

9. Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi's syndrome.

Authors: T Igarashi; H Kawato; S Kamoshita; K Nosaka; K Seiya; H Hayakawa
Journal: Pediatr Nephrol Date: 1992-11 Impact factor: 3.714

Tubulointerstitial nephritis and uveitis: an immunological disorder?

1. Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand.

Review 2. Biology of human immunoglobulin G Fc receptors.

Review 3. Autoimmune myocarditis: a paradigm of post-infection autoimmune disease.

4. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

5. A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy.

Review 6. Idiopathic acute interstitial nephritis and uveitis in the adult. Report of 1 case and review of the literature.

7. Acute interstitial nephritis and iritis. Renal-ocular syndrome.

Review 8. Acute interstitial nephritis in children: a report of 13 cases and review of the literature.

9. Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi's syndrome.

10. Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1. A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation.

2. Cytokine dynamics in a 14-year-old girl with tubulointerstitial nephritis and uveitis syndrome.

3. Tubulointerstitial nephritis and uveitis syndrome associated with hyperthyroidism.

4. Successful treatment of tubulointerstitial nephritis and uveitis with steroid and azathioprine in a 12-year-old boy.

5. Tubulointerstitial nephritis and uveitis (TINU) syndrome: epidemiology, diagnosis and management.