Literature DB >> 7794258

Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats.

T Funahashi1, I Shimomura, H Hiraoka, T Arai, M Takahashi, T Nakamura, S Nozaki, S Yamashita, K Takemura, K Tokunaga.   

Abstract

A responsible gene of genetically obese (ob/ob) mouse has recently been isolated. Genetic disruption of ob gene causes massive obesity. To elucidate the pathophysiological regulation of ob gene, we examined the gene expression in fat tissues of a non-genetical obese model, VMH-lesioned rats. The ob mRNA was identified in both subcutaneous and mesenteric fat tissues in the control rats. In VMH-lesioned rats, the abundance of ob mRNA increased after the gain of body weight and marked expression was observed on 15th day after making VMH lesion. These data suggest that ob gene might be up-regulated with fat accumulation even in non-genetically obese animals.

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Year:  1995        PMID： 7794258     DOI： 10.1006/bbrc.1995.1837

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

Review 1.  Transcription, adipocyte differentiation, and obesity.

Authors:  J Auwerx; G Martin; M Guerre-Millo; B Staels
Journal:  J Mol Med (Berl)       Date:  1996-07       Impact factor: 4.599

2.  Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism.

Authors:  S Sasaki; A C Clutter; D Pomp
Journal:  Mamm Genome       Date:  1996-06       Impact factor: 2.957

3.  Ovarian action of leptin: effects on insulin-like growth factor-I-stimulated function of granulosa and thecal cells.

Authors:  L J Spicer; C S Chamberlain; C C Francisco
Journal:  Endocrine       Date:  2000-02       Impact factor: 3.633

4.  Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.

Authors:  P De Vos; A M Lefebvre; S G Miller; M Guerre-Millo; K Wong; R Saladin; L G Hamann; B Staels; M R Briggs; J Auwerx
Journal:  J Clin Invest       Date:  1996-08-15       Impact factor: 14.808

5.  Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

Authors:  H Fei; H J Okano; C Li; G H Lee; C Zhao; R Darnell; J M Friedman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-24       Impact factor: 11.205

6.  Potassium channel dysfunction in hypothalamic glucose-receptive neurones of obese Zucker rats.

Authors:  I C Rowe; P R Boden; M L Ashford
Journal:  J Physiol       Date:  1996-12-01       Impact factor: 5.182

7.  Leptin actions on food intake and body temperature are mediated by IL-1.

Authors:  G N Luheshi; J D Gardner; D A Rushforth; A S Loudon; N J Rothwell
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

8.  Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system.

Authors:  P Trayhurn; J S Duncan; D V Rayner
Journal:  Biochem J       Date:  1995-11-01       Impact factor: 3.857

9.  Acute Blockade of PACAP-Dependent Activity in the Ventromedial Nucleus of the Hypothalamus Disrupts Leptin-Induced Behavioral and Molecular Changes in Rats.

Authors:  Matthew M Hurley; Eden M Anderson; Christopher Chen; Brian Maunze; Evan M Hess; Megan E Block; Neerali Patel; Zane Cooper; Riley McCoy; Tanya Dabra; William Conley; Michael J Reilly; Matthew Hearing; SuJean Choi
Journal:  Neuroendocrinology       Date:  2019-06-06       Impact factor: 4.914

10.  Early and late stimulation of ob mRNA expression in meal-fed and overfed rats.

Authors:  R B Harris; T G Ramsay; S R Smith; R C Bruch
Journal:  J Clin Invest       Date:  1996-05-01       Impact factor: 14.808
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