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Literature DB >> 7794012

Modulation of the adherence of human polymorphonuclear leukocytes by cadmium and nickel: sexual differences.

Abstract

The effect of cadmium (xenobiotic element) and nickel (ultra-trace bioelement) on the adherence to plastic of peripheral polymorphonuclear leukocytes (PMNs) from male (M-PMNs) and female (F-PMNs) donors was analyzed. Exposure of PMNs to either metal stimulated adherence, mainly the early adherence (8 min). A sex influence on the adherence was observed. Up to 45 min of incubation, M-PMNs adhered more than F-PMNs. This sexual dimorphism also took place in the case of metal stimulation. Cadmium and nickel enhanced early spontaneous adherence of cells from either sex, but only the late adherence (25 min) of F-PMNs. The adherence stimulation was generally greater in F-PMNs, but M-PMNs achieved higher adherence levels. Nickel was more effective than cadmium in enhancing the adherence, especially the early adherence of F-PMNs.

Entities: Chemical Species

Mesh：

Substances：
Cadmium
Nickel

Year: 1995 PMID： 7794012 DOI： 10.1007/bf00213080

Source DB: PubMed Journal: Arch Environ Contam Toxicol ISSN： 0090-4341 Impact factor: 2.804

32 in total

Review 1. Lymphocyte interactions with endothelial cells.

Authors: Y Shimizu; W Newman; Y Tanaka; S Shaw
Journal: Immunol Today Date: 1992-03

Review 2. Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers.

Authors: R Pardi; L Inverardi; J R Bender
Journal: Immunol Today Date: 1992-06

3. Sulfhydryl reducing agents promote neutrophil adherence without increasing surface expression of CD11b/CD18 (Mac-1, Mo1).

Authors: B R Schwartz; J M Harlan
Journal: Biochem Biophys Res Commun Date: 1989-11-30 Impact factor: 3.575

1. Free peripheral sulfhydryl groups, CD11/CD18 integrins, and calcium are required in the cadmium and nickel enhancement of human-polymorphonuclear leukocyte adherence.

Authors: M Hernández; M Macia
Journal: Arch Environ Contam Toxicol Date: 1996-05 Impact factor: 2.804

1 in total

Modulation of the adherence of human polymorphonuclear leukocytes by cadmium and nickel: sexual differences.

Review 1. Lymphocyte interactions with endothelial cells.

Review 2. Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers.

3. Sulfhydryl reducing agents promote neutrophil adherence without increasing surface expression of CD11b/CD18 (Mac-1, Mo1).

4. Increased neutrophil mobilization and decreased chemotaxis during cortisol and epinephrine infusions.

5. The role of sulfhydryl groups in human neutrophil adhesion, movement and particle ingestion.

6. Toxicity to alveolar macrophages in rats following parenteral injection of nickel chloride.

7. Interferon-alpha and dexamethasone inhibit adhesion of T cells to endothelial cells and synovial cells.

8. Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function.

9. Mononuclear cell subsets in the nickel-allergic reaction in vitro and in vivo.

10. Immunologic effects of nickel: I. Suppression of cellular and humoral immunity.

1. Free peripheral sulfhydryl groups, CD11/CD18 integrins, and calcium are required in the cadmium and nickel enhancement of human-polymorphonuclear leukocyte adherence.