Literature DB >> 7793896

nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa.

H Fukuda1, M Hosaka, S Iyobe, N Gotoh, T Nishino, K Hirai.   

Abstract

Quinolone resistance gene nqr-T91 in a clinical isolate of Pseudomonas aeruginosa P1481 was cotransducible with catA1 in P. aeruginosa PAO. The nqr-T91 transductant, PKH-T91, was resistant to norfloxacin, imipenem, and chloramphenicol and showed less norfloxacin accumulation than the parent strain did. Loss of the 46-kDa outer membrane protein (D2) and an increase in the 50-kDa outer membrane protein in PKH-T91 were observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Lipopolysaccharides in the transductant were also changed. These alterations were considered to be related to lower levels of norfloxacin accumulation in PKH-T91. These genetic and biochemical properties suggested that an nfxC type of quinolone-resistant mutation occurred in a clinical isolate of P. aeruginosa P1481.

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Year:  1995        PMID： 7793896      PMCID： PMC162629          DOI： 10.1128/AAC.39.3.790

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

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Authors:  H Matsumoto; S Ohta; R Kobayashi; Y Terawaki
Journal:  Mol Gen Genet       Date:  1978-11-29

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

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Authors:  H Matsumoto; T Nakazawa; S Ohta; Y Terawaki
Journal:  Genet Res       Date:  1981-12       Impact factor: 1.588

4.  Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa.

Authors:  K Hirai; S Suzue; T Irikura; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

5.  Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12.

Authors:  K Hirai; H Aoyama; S Suzue; T Irikura; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1986-08       Impact factor: 5.191

6.  Resistance of Pseudomonas aeruginosa PAO to nalidixic acid and low levels of beta-lactam antibiotics: mapping of chromosomal genes.

Authors:  M Rella; D Haas
Journal:  Antimicrob Agents Chemother       Date:  1982-08       Impact factor: 5.191

7.  Prevalence of fluoroquinolone resistance in Europe. Study Group 'Bacterial Resistance' of the Paul-Ehrlich-Society for Chemotherapy e. V.

Authors:  M Kresken; D Hafner; H Mittermayer; L Verbist; E Bergogne-Bérézin; H Giamarellou; S Esposito; B van Klingeren; F H Kayser; D S Reeves
Journal:  Infection       Date:  1994       Impact factor: 3.553

8.  Ciprofloxacin therapy of infections caused by Pseudomonas aeruginosa and other resistant bacteria.

Authors:  L J Eron; L Harvey; D L Hixon; D M Poretz
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191

9.  Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels.

Authors:  P J Hitchcock; T M Brown
Journal:  J Bacteriol       Date:  1983-04       Impact factor: 3.490

10.  Oral ciprofloxacin therapy of infections due to Pseudomonas aeruginosa.

Authors:  B E Scully; H C Neu; M F Parry; W Mandell
Journal:  Lancet       Date:  1986-04-12       Impact factor: 79.321
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  29 in total

1.  Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa.

Authors:  T Köhler; S F Epp; L K Curty; J C Pechère
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

2.  Role of putative loops 2 and 3 in imipenem passage through the specific porin OprD of Pseudomonas aeruginosa.

Authors:  M M Ochs; M Bains; R E Hancock
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191

Review 3.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

4.  Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids.

Authors:  M M Ochs; M P McCusker; M Bains; R E Hancock
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

5.  mexEF-oprN multidrug efflux operon of Pseudomonas aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol.

Authors:  Hossam Fetar; Christie Gilmour; Rachael Klinoski; Denis M Daigle; Charles R Dean; Keith Poole
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

6.  Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa.

Authors:  H Mouneimné; J Robert; V Jarlier; E Cambau
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

7.  Conservation of the multidrug resistance efflux gene oprM in Pseudomonas aeruginosa.

Authors:  N Bianco; S Neshat; K Poole
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

Review 8.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

Review 9.  Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

Authors:  Lucía Fernández; Robert E W Hancock
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132

10.  A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms.

Authors:  A Brooun; S Liu; K Lewis
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191
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