Literature DB >> 7793890

Use of cryomicrotomy to study gastric diffusion of amoxicillin in guinea pigs.

A Lozniewski1, M Weber, J D De Korwin, M C Conroy, P Franck, J Floquet, A Le Faou, J C Burdin.   

Abstract

Cryomicrotomy has been used as a new technique for removing gastric mucosae from adult guinea pigs for the study of amoxicillin secretion across gastric mucosae. This method allowed a very regular thickness of the removed surface layer of mucosa to be obtained with good reproducibility. Gastric superficial mucosa concentrations and gastric juice concentrations of amoxicillin were determined 1, 2, and 4 h after intramuscular administration (50 mg/kg) in 21 guinea pigs by a microbiological method. No antibiotic was detected in gastric samples at 4 h, except for a low-level mucosal concentration in one animal, thus indicating the short time that amoxicillin is present in gastric samples.

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Year:  1995        PMID： 7793890      PMCID： PMC162622          DOI： 10.1128/AAC.39.3.766

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  In vitro activities of new oral beta-lactams and macrolides against Campylobacter pylori.

Authors:  J A García-Rodríguez; J E García Sánchez; M I García García; E García Sánchez; J L Muñoz Bellido
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

2.  Bactericidal activity of antimicrobial agents against slowly growing Helicobacter pylori.

Authors:  M R Millar; J Pike
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

3.  Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment.

Authors:  E A Rauws; W Langenberg; H J Houthoff; H C Zanen; G N Tytgat
Journal:  Gastroenterology       Date:  1988-01       Impact factor: 22.682

4.  Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents.

Authors:  T Lambert; F Mégraud; G Gerbaud; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1986-09       Impact factor: 5.191

Review 5.  Role of pharmacokinetics in the outcome of infections.

Authors:  G L Drusano
Journal:  Antimicrob Agents Chemother       Date:  1988-03       Impact factor: 5.191

6.  Local gastric and serum amoxicillin concentrations after different oral application forms.

Authors:  M P Cooreman; P Krausgrill; K J Hengels
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

7.  Bactericidal effect of amoxicillin on Helicobacter pylori in an in vitro model using epithelial cells.

Authors:  F Megraud; H Lamouliatte; L Boyanova
Journal:  Antimicrob Agents Chemother       Date:  1991-05       Impact factor: 5.191

8.  Guinea pig model for antibiotic transport across gastric mucosa: inhibitory tissue concentrations of clindamycin against Helicobacter pylori (Campylobacter pylori) following two separate dose regimens.

Authors:  T U Westblom; D E Duriex; E Madan; R B Belshe
Journal:  Antimicrob Agents Chemother       Date:  1990-01       Impact factor: 5.191

9.  The minimum inhibitory and bactericidal concentrations of antibiotics and anti-ulcer agents against Campylobacter pyloridis.

Authors:  C S Goodwin; P Blake; E Blincow
Journal:  J Antimicrob Chemother       Date:  1986-03       Impact factor: 5.790

10.  Inhibitory antimicrobial concentrations against Campylobacter pylori in gastric mucosa.

Authors:  C A McNulty; J C Dent; G A Ford; S P Wilkinson
Journal:  J Antimicrob Chemother       Date:  1988-11       Impact factor: 5.790
  10 in total
  2 in total

1.  In vitro assessment of gastric mucosal transfer of anti-Helicobacter therapeutic agents.

Authors:  A F Goddard; R C Spiller
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

2.  Gastric penetration of amoxicillin in a human Helicobacter pylori-infected xenograft model.

Authors:  A Lozniewski; A Duprez; C Renault; F Muhale; M C Conroy; M Weber; A Le Faou; F Jehl
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191
  2 in total

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