Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection.

Literature DB >> 7793884

(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection.

T W Vahlenkamp¹, A De Ronde, J Balzarini, L Naesens, E De Clercq, M J van Eijk, M C Horzinek, H F Egberink.

Abstract

The antiviral efficacy of acyclic nucleoside phosphonates, including 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine [(R)-PMPDAP] against feline immunodeficiency virus (FIV) infection was determined. (R)-PMPDAP showed the highest selectivity index (> 2,000) in vitro. Treatment of experimentally FIV-infected asymptomatic cats with PMEA or (R)-PMPDAP had no effect on the CD4+/CD8+ ratio. However, mean plasma viral RNA concentrations decreased significantly in the (R)-PMPDAP-treated cats. Our data show that, in comparison to PMEA, (R)-PMPDAP is a more potent and less toxic inhibitor of FIV replication both in vitro and in vivo.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1995 PMID： 7793884 PMCID： PMC162616 DOI： 10.1128/AAC.39.3.746

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

28 in total

1. Characterization of monoclonal antibodies to feline T lymphocytes and their use in the analysis of lymphocyte tissue distribution in the cat.

Authors: M B Tompkins; D H Gebhard; H R Bingham; M J Hamilton; W C Davis; W A Tompkins
Journal: Vet Immunol Immunopathol Date: 1990-12 Impact factor: 2.046

2. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.

Authors: R Pauwels; J Balzarini; M Baba; R Snoeck; D Schols; P Herdewijn; J Desmyter; E De Clercq
Journal: J Virol Methods Date: 1988-08 Impact factor: 2.014

3. Acquired immune dysfunction in cats with experimentally induced feline immunodeficiency virus infection: comparison of short-term and long-term infections.

Authors: J E Barlough; C D Ackley; J W George; N Levy; R Acevedo; P F Moore; B A Rideout; M D Cooper; N C Pedersen
Journal: J Acquir Immune Defic Syndr (1988) Date: 1991

4. Direct comparisons of inhibitor sensitivities of reverse transcriptases from feline and human immunodeficiency viruses.

Authors: T W North; R C Cronn; K M Remington; R T Tandberg
Journal: Antimicrob Agents Chemother Date: 1990-08 Impact factor: 5.191

5. Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission.

Authors: J K Yamamoto; H Hansen; E W Ho; T Y Morishita; T Okuda; T R Sawa; R M Nakamura; N C Pedersen
Journal: J Am Vet Med Assoc Date: 1989-01-15 Impact factor: 1.936

6. Quantitative analysis of HIV-1 proviral DNA in peripheral blood mononuclear cells from patients with AIDS or ARC: decrease of proviral DNA content following treatment with 2',3'-dideoxyinosine (ddI).

Authors: S Aoki; R Yarchoan; R V Thomas; J M Pluda; K Marczyk; S Broder; H Mitsuya
Journal: AIDS Res Hum Retroviruses Date: 1990-11 Impact factor: 2.205

7. Measurement of HIV virus load and genotypic resistance by gene amplification in asymptomatic subjects treated with combination therapy.

Authors: M Holodniy; D Katzenstein; M Winters; J Montoya; R Shafer; M Kozal; M Ragni; T C Merigan
Journal: J Acquir Immune Defic Syndr (1988) Date: 1993-04

8. The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.

Authors: J Balzarini; R Pauwels; M Baba; P Herdewijn; E de Clercq; S Broder; D G Johns
Journal: Biochem Pharmacol Date: 1988-03-01 Impact factor: 5.858

9. 9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections.

Authors: J D Gangemi; R M Cozens; E De Clercq; J Balzarini; H K Hochkeppel
Journal: Antimicrob Agents Chemother Date: 1989-11 Impact factor: 5.191

10. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome.

Authors: N C Pedersen; E W Ho; M L Brown; J K Yamamoto
Journal: Science Date: 1987-02-13 Impact factor: 47.728

12 in total

1. Feline foamy virus adversely affects feline mesenchymal stem cell culture and expansion: implications for animal model development.

Authors: Boaz Arzi; Amir Kol; Brian Murphy; Naomi J Walker; Joshua A Wood; Kaitlin Clark; Frank J M Verstraete; Dori L Borjesson
Journal: Stem Cells Dev Date: 2014-12-31 Impact factor: 3.272

2. Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.

Authors: J Balzarini; T Vahlenkamp; H Egberink; K Hartmann; M Witvrouw; C Pannecouque; P Casara; J F Navé; E De Clercq
Journal: Antimicrob Agents Chemother Date: 1997-03 Impact factor: 5.191

Review 3. In search of a selective antiviral chemotherapy.

Authors: E De Clercq
Journal: Clin Microbiol Rev Date: 1997-10 Impact factor: 26.132

4. Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection.

Authors: Jan Balzarini; Sigrid Hatse; Kurt Vermeire; Katrien Princen; Stefano Aquaro; Carlo-Federico Perno; Erik De Clercq; Herman Egberink; Guy Vanden Mooter; Willy Peumans; Els Van Damme; Dominique Schols
Journal: Antimicrob Agents Chemother Date: 2004-10 Impact factor: 5.191