M Harrison-Woolrych1, R Robinson. 1. Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, United Kingdom.
Abstract
OBJECTIVE: To challenge the conventional belief that leiomyomata are estrogen-dependent tumors by presentation of a case report suggesting high-dose progestogen therapy is associated with a dramatic increase in size of a fibroid uterus. DESIGN: Case report. SETTING: British university hospital. PATIENT: One white woman treated with tamoxifen and high-dose megestrol acetate for breast carcinoma. INTERVENTIONS: Megestrol acetate therapy withdrawn. MAIN OUTCOME MEASURE: Uterine size. RESULTS: While taking tamoxifen and high-dose megestrol acetate, the patient suffered a dramatic increase in size of her fibroid uterus, which reversed when the progestogen was withdrawn. CONCLUSION: This case report suggests that P may be important in fibroid growth.
OBJECTIVE: To challenge the conventional belief that leiomyomata are estrogen-dependent tumors by presentation of a case report suggesting high-dose progestogen therapy is associated with a dramatic increase in size of a fibroid uterus. DESIGN: Case report. SETTING: British university hospital. PATIENT: One white woman treated with tamoxifen and high-dose megestrol acetate for breast carcinoma. INTERVENTIONS:Megestrol acetate therapy withdrawn. MAIN OUTCOME MEASURE: Uterine size. RESULTS: While taking tamoxifen and high-dose megestrol acetate, the patient suffered a dramatic increase in size of her fibroid uterus, which reversed when the progestogen was withdrawn. CONCLUSION: This case report suggests that P may be important in fibroid growth.
Authors: Lauren E Prusinski Fernung; Kimya Jones; Aymara Mas; Daniel Kleven; Jennifer L Waller; Ayman Al-Hendy Journal: Am J Pathol Date: 2018-08-01 Impact factor: 4.307
Authors: Terrence D Lewis; Minnie Malik; Joy Britten; Angelo Macapagal San Pablo; William H Catherino Journal: Biomed Res Int Date: 2018-01-28 Impact factor: 3.411