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Literature DB >> 7789063

A case of Werner's syndrome associated with systemic lupus erythematosus.

A Kogure¹, Y Ohshima, N Watanabe, T Ohba, M Miyata, M Ohara, T Nishimaki, R Kasukawa.

Abstract

The case of a 40-year-old woman with Werner's syndrome associated with systemic lupus erythematosus (SLE) is reported. The patient exhibited short stature, slender extremities, thinned hair, high-pitched voice, cataracts, ulceration of the fingers, and mental retardation. Malar erythema, photosensitivity, and proteinuria had been noted since age 34. The serum contained high titers of antibodies to dsDNA, Sm, nRNP, and SS-A/Ro. The simultaneous presence of Werner's syndrome and SLE could be a coincidental occurrence of the two diseases, although it might be due to an abnormality in replication or degeneration of DNA leading to the development of both diseases.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1995 PMID： 7789063 DOI： 10.1007/bf02214944

Source DB: PubMed Journal: Clin Rheumatol ISSN： 0770-3198 Impact factor: 2.980

13 in total

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Authors: D Monti; A Cossarizza; M Chiricolo; P Vannini; A Ciavarella; C Franceschi
Journal: Ann N Y Acad Sci Date: 1992-11-21 Impact factor: 5.691

2. Studies on the molecular-genetic basis of replicative senescence in Werner syndrome and normal fibroblasts.

Authors: S Goldstein; S Murano; H Benes; E J Moerman; R A Jones; R Thweatt; R J Shmookler Reis; B H Howard
Journal: Exp Gerontol Date: 1989 Impact factor: 4.032

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Authors: Y Fujiwara; T Higashikawa; M Tatsumi
Journal: J Cell Physiol Date: 1977-09 Impact factor: 6.384

4. Werner's syndrome (progeria of the adult) and Rothmund's syndrome: two types of closely related heredofamilial atrophic dermatoses with juvenile cataracts and endocrine features; a critical study with five new cases. S.J. Tannhauser. Reprinted from Annals of Internal Medicine, 23:559 (1945).

Authors:
Journal: Adv Exp Med Biol Date: 1985 Impact factor: 2.622

5. Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature.

Authors: M Goto; K Tanimoto; Y Horiuchi; T Sasazuki
Journal: Clin Genet Date: 1981-01 Impact factor: 4.438

6. Werner's syndrome: twenty-four cases with a review of the Japanese medical literature.

Authors: K Murata; H Nakashima
Journal: J Am Geriatr Soc Date: 1982-05 Impact factor: 5.562

7. Studies on synthesis of interleukin-6 and gammaglobulin in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.

Authors: C Hashimoto
Journal: Tohoku J Exp Med Date: 1990-12 Impact factor: 1.848

A case of Werner's syndrome associated with systemic lupus erythematosus.

1. Sensitivity to genotoxic agents and immunological status in a case of Werner's syndrome.

2. Studies on the molecular-genetic basis of replicative senescence in Werner syndrome and normal fibroblasts.

3. A retarded rate of DNA replication and normal level of DNA repair in Werner's syndrome fibroblasts in culture.

4. Werner's syndrome (progeria of the adult) and Rothmund's syndrome: two types of closely related heredofamilial atrophic dermatoses with juvenile cataracts and endocrine features; a critical study with five new cases. S.J. Tannhauser. Reprinted from Annals of Internal Medicine, 23:559 (1945).

5. Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature.

6. Werner's syndrome: twenty-four cases with a review of the Japanese medical literature.

7. Studies on synthesis of interleukin-6 and gammaglobulin in peripheral blood mononuclear cells of patients with systemic lupus erythematosus.

8. Immunological abnormalities of aging: an analysis of T lymphocyte subpopulations of Werner's syndrome.

9. The 1982 revised criteria for the classification of systemic lupus erythematosus.

10. HLA antigens associated with systemic lupus erythematosus in Japan.

1. Development of autoimmunity in mice lacking DNA topoisomerase 3beta.

2. A case of Myhre syndrome mimicking juvenile scleroderma.