BACKGROUND: In previous studies cognitive impairment in depressed elderly in-patients tends to be associated with a late onset of depression. This study tests the hypothesis that cognitive impairment is associated with depression only in elderly individuals with no history of psychiatric illness. METHOD: We investigated an age-stratified sample of 4051 elderly people living in the community, aged between 65 and 84 (AMSTEL). The relationship between depression (GMS-AGECAT diagnosis) and scores on the Mini Mental State Examination was studied in subjects with and without a reported psychiatric history (CAMDEX questionnaire). RESULTS: Low MMSE scores (MMSE < or = 25) were only associated with depression in subjects with no psychiatric history (young/old: OR = 2.75, 95% CI = 1.83, 4.19; old/old: OR = 2.21, 95% CI = 1.61, 3.03). CONCLUSIONS: We concluded that the combination of cognitive impairment and first-episode depression in elderly individuals may indicate cerebral deterioration. Depression as such may not be associated with cognitive impairment.
BACKGROUND: In previous studies cognitive impairment in depressed elderly in-patients tends to be associated with a late onset of depression. This study tests the hypothesis that cognitive impairment is associated with depression only in elderly individuals with no history of psychiatric illness. METHOD: We investigated an age-stratified sample of 4051 elderly people living in the community, aged between 65 and 84 (AMSTEL). The relationship between depression (GMS-AGECAT diagnosis) and scores on the Mini Mental State Examination was studied in subjects with and without a reported psychiatric history (CAMDEX questionnaire). RESULTS: Low MMSE scores (MMSE < or = 25) were only associated with depression in subjects with no psychiatric history (young/old: OR = 2.75, 95% CI = 1.83, 4.19; old/old: OR = 2.21, 95% CI = 1.61, 3.03). CONCLUSIONS: We concluded that the combination of cognitive impairment and first-episode depression in elderly individuals may indicate cerebral deterioration. Depression as such may not be associated with cognitive impairment.
Authors: Martina Ballmaier; Anand Kumar; Virginia Elderkin-Thompson; Katherine L Narr; Eileen Luders; Paul M Thompson; Cornelius Hojatkashani; Daniel Pham; Andreas Heinz; Arthur W Toga Journal: Neuropsychopharmacology Date: 2007-08-22 Impact factor: 7.853
Authors: Lin Xu; Chao Qiang Jiang; Tai Hing Lam; Wei Sen Zhang; Stacey Shawn Cherny; G Neil Thomas; Kar Keung Cheng Journal: Sleep Date: 2014-11-01 Impact factor: 5.849