Low-dose aspirin therapy in obstetrics.

The results of four large controlled clinical trials, encompassing over 13,000 pregnant women, indicate that low-dose aspirin is of benefit in the prevention of pre-eclampsia in women at high risk. The preventive effect on fetal growth retardation seems to be small, and no therapeutic benefits could be established. Low-dose aspirin appears to be safe for mother, fetus, and neonate.