Literature DB >> 7787076

Ciliary beat frequency is controlled by a dynein light chain phosphorylation.

P Satir1, K Barkalow, T Hamasaki.   

Abstract

cAMP-dependent phosphorylation of a 29-kDa axonemal polypeptide (p29) increases the swimming speed of permeabilized Paramecium and in vitro translocation velocity of bovine brain microtubules over 22S dynein extracted from Paramecium axonemes. A quantitative relationship between microtubule translocation velocity and beat frequency is developed. We conclude that p29 acts as a regulatory light chain of outer arm dynein in the control of ciliary beat frequency.

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Year:  1995        PMID： 7787076      PMCID： PMC1281925     

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  2 in total

1.  cAMP-stimulated phosphorylation of an axonemal polypeptide that copurifies with the 22S dynein arm regulates microtubule translocation velocity and swimming speed in Paramecium.

Authors:  T Hamasaki; K Barkalow; J Richmond; P Satir
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

2.  Regulation of 22S dynein by a 29-kD light chain.

Authors:  K Barkalow; T Hamasaki; P Satir
Journal:  J Cell Biol       Date:  1994-08       Impact factor: 10.539
  2 in total
  5 in total

1.  Continuous mucociliary transport by primary human airway epithelial cells in vitro.

Authors:  Patrick R Sears; Wei-Ning Yin; Lawrence E Ostrowski
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-05-15       Impact factor: 5.464

2.  Inhibition of protein phosphatase 1 reverses alcohol-induced ciliary dysfunction.

Authors:  Michael E Price; Jacqueline A Pavlik; Joseph H Sisson; Todd A Wyatt
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-01-09       Impact factor: 5.464

3.  The role of cGMP in the regulation of rabbit airway ciliary beat frequency.

Authors:  Luo Zhang; Michael J Sanderson
Journal:  J Physiol       Date:  2003-06-20       Impact factor: 5.182

4.  Computational modelling elucidates the mechanism of ciliary regulation in health and disease.

Authors:  Nikolay V Kotov; Declan G Bates; Antonina N Gizatullina; Bulat Gilaziev; Rustem N Khairullin; Michael Z Q Chen; Ignat Drozdov; Yoshinori Umezawa; Christian Hundhausen; Alexey Aleksandrov; Xing-gang Yan; Sarah K Spurgeon; C Mark Smales; Najl V Valeyev
Journal:  BMC Syst Biol       Date:  2011-09-15

5.  Bend propagation drives central pair rotation in Chlamydomonas reinhardtii flagella.

Authors:  David R Mitchell; Masako Nakatsugawa
Journal:  J Cell Biol       Date:  2004-08-30       Impact factor: 10.539
  5 in total

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