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Literature DB >> 7786011

Comparative in vitro activities of L-695,256, a novel carbapenem, against gram-positive bacteria.

G Malanoski¹, L Collins, C T Eliopoulos, R C Moellering, G M Eliopoulos.

Abstract

The in vitro activity of a prototype 2-aryl carbapenem, L-695,256, against gram-positive bacteria was examined. All streptococci and oxacillin-susceptible and -resistant staphylococci were inhibited at concentrations of < or = 0.125, < or = 0.125, and 4 micrograms/ml, respectively. The activity of L-695,256 was superior to that of imipenem against other organisms intrinsically resistant to beta-lactams.

Entities: Chemical

Mesh：

Substances：

Year: 1995 PMID： 7786011 PMCID： PMC162669 DOI： 10.1128/AAC.39.4.990

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

Review 1. Classification of beta-lactamases: groups 1, 2a, 2b, and 2b'.

Authors: K Bush
Journal: Antimicrob Agents Chemother Date: 1989-03 Impact factor: 5.191

Review 2. Methicillin-resistant Staphylococcus aureus.

Authors: W Brumfitt; J Hamilton-Miller
Journal: N Engl J Med Date: 1989-05-04 Impact factor: 91.245

3. One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin.

Authors: R Williamson; C le Bouguénec; L Gutmann; T Horaud
Journal: J Gen Microbiol Date: 1985-08

4. Type I beta-lactamases of gram-negative bacteria: interactions with beta-lactam antibiotics.

Authors: C C Sanders; W E Sanders
Journal: J Infect Dis Date: 1986-11 Impact factor: 5.226

5. Low-level colonization of hospitalized patients with methicillin-resistant coagulase-negative staphylococci and emergence of the organisms during surgical antimicrobial prophylaxis.

Authors: D S Kernodle; N L Barg; A B Kaiser
Journal: Antimicrob Agents Chemother Date: 1988-02 Impact factor: 5.191

6. Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus.

Authors: H F Chambers; M Sachdeva; S Kennedy
Journal: J Infect Dis Date: 1990-09 Impact factor: 5.226

4. In vitro and in vivo activities of novel 2-(thiazol-2-ylthio)-1beta-methylcarbapenems with potent activities against multiresistant gram-positive bacteria.

Authors: Yutaka Ueda; Makoto Sunagawa
Journal: Antimicrob Agents Chemother Date: 2003-08 Impact factor: 5.191

4 in total

Comparative in vitro activities of L-695,256, a novel carbapenem, against gram-positive bacteria.

Review 1. Classification of beta-lactamases: groups 1, 2a, 2b, and 2b'.

Review 2. Methicillin-resistant Staphylococcus aureus.

3. One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin.

4. Type I beta-lactamases of gram-negative bacteria: interactions with beta-lactam antibiotics.

5. Low-level colonization of hospitalized patients with methicillin-resistant coagulase-negative staphylococci and emergence of the organisms during surgical antimicrobial prophylaxis.

6. Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus.

7. Comparative in vitro activity of SM7338, a new carbapenem antimicrobial agent.

8. A common-source outbreak of Staphylococcus epidermidis infections among patients undergoing cardiac surgery.

9. Involvement of multiple genetic determinants in high-level methicillin resistance in Staphylococcus aureus.

10. In vitro activity of biapenem against clinical isolates of gram-positive and gram-negative bacteria.

Review 1. Antibiotic resistance: a current perspective.

Review 2. The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics.

3. In vitro and in vivo antibacterial activities of SM-216601, a new broad-spectrum parenteral carbapenem.

4. In vitro and in vivo activities of novel 2-(thiazol-2-ylthio)-1beta-methylcarbapenems with potent activities against multiresistant gram-positive bacteria.