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Literature DB >> 7786007

Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.

C K Chu¹, T Ma, K Shanmuganathan, C Wang, Y Xiang, S B Pai, G Q Yao, J P Sommadossi, Y C Cheng.

Abstract

A novel anti-hepatitis B virus (anti-HBV) agent, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU), was synthesized and found to be a potent anti-HBV and anti-Epstein-Barr virus agent. Its in vitro potency was evaluated in 2.2.15 and H1 cells for anti-HBV and anti-Epstein-Barr virus activities, respectively. In vitro cytotoxicity in MT2, CEM, 2.2.15, and H1 cells was also assessed, and the results indicated high antiviral selectivities of L-FMAU in these cells.

Entities: Chemical Disease Gene Species

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Year: 1995 PMID： 7786007 PMCID： PMC162665 DOI： 10.1128/AAC.39.4.979

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

1. Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.

Authors: C N Chang; S L Doong; J H Zhou; J W Beach; L S Jeong; C K Chu; C H Tsai; Y C Cheng; D Liotta; R Schinazi
Journal: J Biol Chem Date: 1992-07-15 Impact factor: 5.157

2. Synthesis and biological effects of 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil.

Authors: T C Chou; X B Kong; M P Fanucchi; Y C Cheng; K Takahashi; K A Watanabe; J J Fox
Journal: Antimicrob Agents Chemother Date: 1987-09 Impact factor: 5.191

3. The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

Authors: J A Coates; N Cammack; H J Jenkinson; I M Mutton; B A Pearson; R Storer; J M Cameron; C R Penn
Journal: Antimicrob Agents Chemother Date: 1992-01 Impact factor: 5.191

4. Nucleosides. 136. Synthesis and antiviral effects of several 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-alkyluracils. Some structure-activity relationships.

Authors: T L Su; K A Watanabe; R F Schinazi; J J Fox
Journal: J Med Chem Date: 1986-01 Impact factor: 7.446

5. Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog.

Authors: H Soudeyns; X I Yao; Q Gao; B Belleau; J L Kraus; N Nguyen-Ba; B Spira; M A Wainberg
Journal: Antimicrob Agents Chemother Date: 1991-07 Impact factor: 5.191

6. Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro.

Authors: G Gosselin; R F Schinazi; J P Sommadossi; C Mathé; M C Bergogne; A M Aubertin; A Kirn; J L Imbach
Journal: Antimicrob Agents Chemother Date: 1994-06 Impact factor: 5.191

7. Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

Authors: S L Doong; C H Tsai; R F Schinazi; D C Liotta; Y C Cheng
Journal: Proc Natl Acad Sci U S A Date: 1991-10-01 Impact factor: 11.205

8. Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line.

Authors: Y Hinuma; M Konn; J Yamaguchi; D J Wudarski; J R Blakeslee; J T Grace
Journal: J Virol Date: 1967-10 Impact factor: 5.103

9. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions.

Authors: M A Sells; A Z Zelent; M Shvartsman; G Acs
Journal: J Virol Date: 1988-08 Impact factor: 5.103

10. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine.

Authors: C H Chen; Y C Cheng
Journal: J Biol Chem Date: 1989-07-15 Impact factor: 5.157

36 in total

1. Inhibition of replication of hepatitis B virus by cytallene in vitro.

Authors: Y L Zhu; S B Pai; S H Liu; K L Grove; B C Jones; C Simons; J Zemlicka; Y C Cheng
Journal: Antimicrob Agents Chemother Date: 1997-08 Impact factor: 5.191

2. Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy.

Authors: Hyo-Suk Lee; Byung Chul Yoo; Kwan Sik Lee; Ju Hyun Kim; Soon-Ho Um; Soo Hyung Ryu; Young-Suk Lee; Young Soo Kim; Kwon Yoo; Joon-Yeol Han; Jae Seok Hwang; Tae-Hun Kim; Jin-Mo Yang; Heon-Ju Lee; Chae Yoon Chon; Mong Cho; Byung Hoon Han; Seong Gyu Hwang; Kwan Soo Byun; Young-Hwa Chung; Se-Hyun Cho; Kwang Cheol Koh; Byung-Ik Kim; Haak Cheoul Kim; Seung Woon Paik; Myung-Seok Lee; Hee-Won Yoo; Cheol Ju Han
Journal: J Gastroenterol Date: 2010-12-23 Impact factor: 7.527

3. Unique metabolism of a novel antiviral L-nucleoside analog, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil: a substrate for both thymidine kinase and deoxycytidine kinase.

Authors: S H Liu; K L Grove; Y C Cheng
Journal: Antimicrob Agents Chemother Date: 1998-04 Impact factor: 5.191

4. Randomized, double-blind study of emtricitabine (FTC) plus clevudine versus FTC alone in treatment of chronic hepatitis B.

Authors: Seng Gee Lim; Zahary Krastev; Tay Meng Ng; Grigor Mechkov; Iskren Andreev Kotzev; Sing Chan; Elsa Mondou; Andrea Snow; Jeff Sorbel; Franck Rousseau
Journal: Antimicrob Agents Chemother Date: 2006-05 Impact factor: 5.191

5. Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.

Authors: Hyo-Joong Kim; Ashoke Sharon; Chandralata Bal; Jianing Wang; Madhan Allu; Zhuhui Huang; Michael G Murray; Leda Bassit; Raymond F Schinazi; Brent Korba; Chung K Chu
Journal: J Med Chem Date: 2009-01-08 Impact factor: 7.446

Review 6. A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease.

Authors: Christopher M Bailey; Karen S Anderson
Journal: Biochim Biophys Acta Date: 2010-01-18