Literature DB >> 7784304

A modified liquid diet of chronic ethanol administration: validation by ethanol withdrawal syndrome in rats.

I T Uzbay1, S O Kayaalp.   

Abstract

The validity of a modified liquid diet prepared from cow's milk, 7.2% ethanol, vitamin A and sucrose mixture has been investigated for chronic ethanol administration in rats. The rats fed by the modified liquid diet lost 3.8% of their body weight along 20 days. The mean ethanol consumption was in the range of 12.6 to 17.6 g kg-1 day-1. The blood ethanol level just before the withdrawal of ethanol was found to be 301.38 +/- 36.68 mg dl-1. A severe ethanol withdrawal syndrome was observed after 20-day exposure to ethanol in the modified liquid diet. The results suggest that the modified liquid diet can be used satisfactorily for chronic ethanol administration in rats.

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Year:  1995        PMID： 7784304     DOI： 10.1016/1043-6618(95)80045-x

Source DB:  PubMed          Journal:  Pharmacol Res        ISSN： 1043-6618            Impact factor:   7.658


  11 in total

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6.  Effects of chronic ethanol administration on serotonin metabolism in the various regions of the rat brain.

Authors:  I T Uzbay; S E Usanmaz; E S Akarsu
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7.  The effects of chronic exposure to ethanol and cigarette smoke on the level of reduced glutathione and malondialdehyde in rat kidney.

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10.  Change of cystine/glutamate antiporter expression in ethanol-dependent rats.

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