Literature DB >> 7784258

Bombesin stimulates c-fos and c-jun mRNAs in small cell lung cancer cells.

M Draoui1, P Chung, M Park, M Birrer, S Jakowlew, T W Moody.   

Abstract

The effects of bombesin/gastrin-releasing peptide (BN/GRP) on c-fos and c-jun gene expression were investigated using small cell lung cancer (SCLC) cells. BN (10 nM) increased c-fos mRNA fivefold using NCI-H345 or NCI-H510 cells. The increase was concentration dependent with 1 nM BN half-maximally increasing c-fos mRNA. Also, the increase in c-fos mRNA caused by BN was time dependent, being maximal after 1 h and returning to basal values after 4 h. GRP and GRP(14-27) but not GRP(1-16) increased c-fos mRNA. BW2258U89 (1 microM), a GRP receptor antagonist, had no effect on basal c-fos but inhibited the increase in c-fos mRNA caused by 10 nM BN. Also, BN transiently increased c-jun mRNA twofold and the increase caused by BN was blocked by BW2258U89. These data suggest that GRP receptors may regulate nuclear oncogene gene expression in SCLC cells.

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Year:  1995        PMID： 7784258     DOI： 10.1016/0196-9781(94)00173-1

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  7 in total

Review 1.  Peptide receptors as cancer drug targets.

Authors:  Terry W Moody
Journal:  Ann N Y Acad Sci       Date:  2019-05-10       Impact factor: 5.691

2.  Bombesin/gastrin-releasing peptide receptor antagonists increase the ability of histone deacetylase inhibitors to reduce lung cancer proliferation.

Authors:  Terry W Moody; Tomoo Nakagawa; Yang Kang; Sonia Jakowlew; Daniel Chan; Robert T Jensen
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

3.  Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes.

Authors:  Ana M Bajo; Andrew V Schally; Magdalena Krupa; Francine Hebert; Kate Groot; Karoly Szepeshazi
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

Review 4.  Bombesin-drug conjugates in targeted therapy for small cell lung cancer.

Authors:  Yichi Zhang; Elizabeth Holland; Anna Dinh; Duc Au; Lichun Sun
Journal:  Am J Cancer Res       Date:  2022-03-15       Impact factor: 6.166

5.  A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells.

Authors:  H C Weber; J Walters; J Leyton; M Casibang; S Purdom; R T Jensen; D H Coy; C Ellis; G Clark; T W Moody
Journal:  Eur J Pharmacol       Date:  2001-01-19       Impact factor: 4.432

6.  Inhibition of growth of OV-1063 human epithelial ovarian cancers and c- jun and c- fos oncogene expression by bombesin antagonists.

Authors:  I Chatzistamou; A V Schally; B Sun; P Armatis; K Szepeshazi
Journal:  Br J Cancer       Date:  2000-10       Impact factor: 7.640

7.  Targeted cytotoxic analogue of bombesin/gastrin-releasing peptide inhibits the growth of H-69 human small-cell lung carcinoma in nude mice.

Authors:  H Kiaris; A V Schally; A Nagy; B Sun; P Armatis; K Szepeshazi
Journal:  Br J Cancer       Date:  1999-11       Impact factor: 7.640
  7 in total

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