| Literature DB >> 7783149 |
M Morita1, K Motoki, K Akimoto, T Natori, T Sakai, E Sawa, K Yamaji, Y Koezuka, E Kobayashi, H Fukushima.
Abstract
Agelasphin-9b, (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-16-methyl-2- [N-((R)-2- hydroxytetracosanoyl)-amino]- 1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and the relationship between their structures and biological activities was examined using several assay systems. From the results, KRN7000, (2S,3S,4R)-1-O-(alpha-D- galactopyranosyl)-2-(N-hexacosanoylamino)-1,3,4-octadecanetriol , was selected as a candidate for clinical application.Entities:
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Year: 1995 PMID： 7783149 DOI： 10.1021/jm00012a018
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446