Literature DB >> 7782280

A sphingomyelin-transferring protein from chicken liver. Use of pyrene-labeled phospholipid.

J Westerman1, K J de Vries, P Somerharju, J L Timmermans-Hereijgers, G T Snoek, K W Wirtz.   

Abstract

A phospholipid transfer protein was purified from chicken liver which, in addition to phosphatidylinositol (PI) and phosphatidylcholine (PC), carries sphingomyelin (SM) between membranes. For comparison, the PI-transfer protein from chicken liver only carries PI and PC. Specificity was established by use of phospholipids that carry a pyrene-labeled acyl chain. Based on the N-terminal sequence and Western blot analysis we conclude that this protein is an isoform of the PI-transfer protein. At increasing length of the pyrene-labeled acyl chain, the isoform expresses a high activity toward SM, a low activity toward PI, and virtually no activity toward PC.

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Year:  1995        PMID： 7782280     DOI： 10.1074/jbc.270.24.14263

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  6 in total

1.  The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phospholipase C-mediated inositol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells.

Authors:  E Cunningham; S K Tan; P Swigart; J Hsuan; V Bankaitis; S Cockcroft
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

Review 2.  Phospholipid transfer proteins revisited.

Authors:  K W Wirtz
Journal:  Biochem J       Date:  1997-06-01       Impact factor: 3.857

3.  Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.

Authors:  Clive P Morgan; Victoria Allen-Baume; Marko Radulovic; Michelle Li; Alison Skippen; Shamshad Cockcroft
Journal:  Biochem J       Date:  2006-09-15       Impact factor: 3.857

4.  Deletion of 24 amino acids from the C-terminus of phosphatidylinositol transfer protein causes loss of phospholipase C-mediated inositol lipid signalling.

Authors:  S Prosser; R Sarra; P Swigart; A Ball; S Cockcroft
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

5.  Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta.

Authors:  C M Van Tiel; C Luberto; G T Snoek; Y A Hannun; K W Wirtz
Journal:  Biochem J       Date:  2000-03-01       Impact factor: 3.857

6.  Phosphatidylinositol transfer protein beta displays minimal sphingomyelin transfer activity and is not required for biosynthesis and trafficking of sphingomyelin.

Authors:  Bruno Ségui; Victoria Allen-Baume; Shamshad Cockcroft
Journal:  Biochem J       Date:  2002-08-15       Impact factor: 3.857
  6 in total

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