Literature DB >> 7781064

Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila.

R L Kelley1, I Solovyeva, L M Lyman, R Richman, V Solovyev, M I Kuroda.   

Abstract

Male-specific lethal-2 (msl-2) is a RING finger protein that is required for X chromosome dosage compensation in Drosophila males. Consistent with the formation of a dosage compensation protein complex, msl-2 colocalizes with the other MSL proteins on the male X chromosome and coimmunoprecipitates with msl-1 from male larval extracts. Ectopic expression of msl-2 in females results in the appearance of the other MSL dosage compensation regulators on the female X chromosomes and decreased female viability. We suggest that msl-2 RNA is the primary target of SxI regulation in the dosage compensation pathway and present a speculative model for the regulation of two distinct modes of dosage compensation by SxI.

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Year:  1995        PMID： 7781064     DOI： 10.1016/0092-8674(95)90007-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  138 in total

1.  Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal.

Authors:  R Singh; H Banerjee; M R Green
Journal:  RNA       Date:  2000-06       Impact factor: 4.942

2.  Quantitative analysis of gene function in the Drosophila embryo.

Authors:  W D Tracey; X Ning; M Klingler; S G Kramer; J P Gergen
Journal:  Genetics       Date:  2000-01       Impact factor: 4.562

3.  Targeting the chromatin-remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities.

Authors:  W Gu; X Wei; A Pannuti; J C Lucchesi
Journal:  EMBO J       Date:  2000-10-02       Impact factor: 11.598

4.  Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila.

Authors:  U Bhadra; M Pal-Bhadra; J A Birchler
Journal:  Genetics       Date:  2000-06       Impact factor: 4.562

Review 5.  Acetylation of histones and transcription-related factors.

Authors:  D E Sterner; S L Berger
Journal:  Microbiol Mol Biol Rev       Date:  2000-06       Impact factor: 11.056

6.  Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila.

Authors:  U Bhadra; M Pal-Bhadra; J A Birchler
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

7.  siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster.

Authors:  Debashish U Menon; Cristian Coarfa; Weimin Xiao; Preethi H Gunaratne; Victoria H Meller
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-03       Impact factor: 11.205

8.  Functional integration of the histone acetyltransferase MOF into the dosage compensation complex.

Authors:  Violette Morales; Tobias Straub; Martin F Neumann; Gabrielle Mengus; Asifa Akhtar; Peter B Becker
Journal:  EMBO J       Date:  2004-05-13       Impact factor: 11.598

9.  Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.

Authors:  Mengqi Lv; Yixiang Yao; Fudong Li; Ling Xu; Lingna Yang; Qingguo Gong; Yong-Zhen Xu; Yunyu Shi; Yu-Jie Fan; Yajun Tang
Journal:  Nucleic Acids Res       Date:  2019-04-08       Impact factor: 16.971

10.  Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system.

Authors:  Yue Zhao; Ken-ichi Takeyama; Shun Sawatsubashi; Saya Ito; Eriko Suzuki; Kaoru Yamagata; Masahiko Tanabe; Shuhei Kimura; Sally Fujiyama; Takashi Ueda; Takuya Murata; Hiroyuki Matsukawa; Yuko Shirode; Alexander P Kouzmenko; Feng Li; Testuya Tabata; Shigeaki Kato
Journal:  Mol Cell Biol       Date:  2008-12-15       Impact factor: 4.272
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