Literature DB >> 7779764

Effect of PCBs on androgen production by suspension of adult rat Leydig cells in vitro.

R Kovacević1, M Vojinović-Miloradov, I Teodorović, S Andrić.   

Abstract

The effects of PCBs (mixture of 2, 3, 4, 5-tetra; 2, 2', 4, 5, 5'-penta; 2, 2', 3, 3', 6, 6'-hexa and 2, 2', 3, 3', 4, 4', 5, 5'-octa congeners) on androgen production were investigated by suspension of Leydig cells from adult rat testis. hCG-stimulated androgen production was significantly inhibited by PCBs while progesterone level was not affected. Progesterone supported testosterone production was also decreased by PCBs, while conversion of androstenedione to testosterone was unchanged. These results suggest that the activity of microsomal enzyme C21 side-chain cleavage P450 was decreased by PCB treatment of Leydig cells in vitro.

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Year:  1995        PMID： 7779764     DOI： 10.1016/0960-0760(95)00060-d

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN： 0960-0760            Impact factor:   4.292


  9 in total

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Authors:  M S Petersen; J Halling; P Weihe; T K Jensen; P Grandjean; F Nielsen; N Jørgensen
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2.  Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men.

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Journal:  Environ Health Perspect       Date:  2009-05-20       Impact factor: 9.031

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Authors:  Kelly K Ferguson; Russ Hauser; Larisa Altshul; John D Meeker
Journal:  Reprod Toxicol       Date:  2012-05-05       Impact factor: 3.143

4.  Acute effects of polychlorinated biphenyl-containing and -free transformer fluids on rat testicular steroidogenesis.

Authors:  S A Andric; T S Kostic; S M Dragisic; N L Andric; S S Stojilkovic; R Z Kovacevic
Journal:  Environ Health Perspect       Date:  2000-10       Impact factor: 9.031

Review 5.  Understanding the human health effects of chemical mixtures.

Authors:  David O Carpenter; Kathleen Arcaro; David C Spink
Journal:  Environ Health Perspect       Date:  2002-02       Impact factor: 9.031

6.  Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p'-DDE) with testosterone levels in adolescent males.

Authors:  Lawrence M Schell; Mia V Gallo; Glenn D Deane; Kyrie R Nelder; Anthony P DeCaprio; Agnes Jacobs
Journal:  Environ Health Perspect       Date:  2013-12-20       Impact factor: 9.031

7.  Chlorinated biphenyls effect on estrogen-related receptor expression, steroid secretion, mitochondria ultrastructure but not on mitochondrial membrane potential in Leydig cells.

Authors:  Agnieszka Milon; Malgorzata Opydo-Chanek; Waclaw Tworzydlo; Jerzy Galas; Laura Pardyak; Alicja Kaminska; Anna Ptak; Malgorzata Kotula-Balak
Journal:  Cell Tissue Res       Date:  2017-03-18       Impact factor: 5.249

8.  Persistent organic pollutants and couple fecundability: a systematic review.

Authors:  Linda G Kahn; Kim G Harley; Eva L Siegel; Yeyi Zhu; Pam Factor-Litvak; Christina A Porucznik; Michele Klein-Fedyshin; Alison E Hipwell
Journal:  Hum Reprod Update       Date:  2021-02-19       Impact factor: 15.610

9.  Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS).

Authors:  Maria Skaalum Petersen; Jónrit Halling; Niels Jørgensen; Flemming Nielsen; Philippe Grandjean; Tina Kold Jensen; Pál Weihe
Journal:  Int J Environ Res Public Health       Date:  2018-08-30       Impact factor: 3.390
  9 in total

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