Literature DB >> 7779701

Does autocrine growth factor secretion form part of a mechanism which paradoxically protects against tumour development?

T Dawson1, D Wynford-Thomas.   

Abstract

Autocrine growth factor secretion has classically been considered as a mechanism by which tumour cells achieve autonomous growth. However, there is now considerable evidence that autocrine circuits operate in the growth regulation of normal adult tissues. Here we consider the possible advantages to the normal epithelial cell of utilising such an external growth factor circuit and suggest that autocrine growth factor secretion, when viewed in a multicellular context, could paradoxically form part of a mechanism for preventing tumour development.

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Year:  1995        PMID： 7779701      PMCID： PMC2033821          DOI： 10.1038/bjc.1995.222

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  29 in total

Review 1.  Natural heterogeneity of thyroid cells: the basis for understanding thyroid function and nodular goiter growth.

Authors:  H Studer; H J Peter; H Gerber
Journal:  Endocr Rev       Date:  1989-05       Impact factor: 19.871

Review 2.  Insulin-like growth factors and their binding proteins.

Authors:  V R Sara; K Hall
Journal:  Physiol Rev       Date:  1990-07       Impact factor: 37.312

Review 3.  Growth factors in development, transformation, and tumorigenesis.

Authors:  M Cross; T M Dexter
Journal:  Cell       Date:  1991-01-25       Impact factor: 41.582

4.  Agent-specific ras oncogene activation in rat thyroid tumours.

Authors:  N R Lemoine; E S Mayall; E D Williams; V Thurston; D Wynford-Thomas
Journal:  Oncogene       Date:  1988-11       Impact factor: 9.867

Review 5.  Insulin-like growth factors; autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments.

Authors:  J M Holly; J A Wass
Journal:  J Endocrinol       Date:  1989-09       Impact factor: 4.286

Review 6.  Tumor secretion of growth factors.

Authors:  W H Daughaday; T F Deuel
Journal:  Endocrinol Metab Clin North Am       Date:  1991-09       Impact factor: 4.741

7.  High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area.

Authors:  Y F Shi; M J Zou; H Schmidt; F Juhasz; V Stensky; D Robb; N R Farid
Journal:  Cancer Res       Date:  1991-05-15       Impact factor: 12.701

8.  Insulin-like growth factor-I: autocrine secretion by human thyroid follicular cells in primary culture.

Authors:  B Tode; M Serio; C M Rotella; G Galli; F Franceschelli; A Tanini; R Toccafondi
Journal:  J Clin Endocrinol Metab       Date:  1989-09       Impact factor: 5.958

9.  Insulin-like growth factor-I stimulates the growth of rat thyroid cells in culture and synergizes the stimulation of DNA synthesis induced by TSH and Graves'-IgG.

Authors:  D Tramontano; G W Cushing; A C Moses; S H Ingbar
Journal:  Endocrinology       Date:  1986-08       Impact factor: 4.736

10.  Reversibility of the malignant phenotype in monoclonal tumours in the mouse.

Authors:  G A Thomas; D Williams; E D Williams
Journal:  Br J Cancer       Date:  1991-02       Impact factor: 7.640
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  3 in total

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Authors:  J R Foster
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2.  TGF-beta cooperates with TGF-alpha to induce the self-renewal of normal erythrocytic progenitors: evidence for an autocrine mechanism.

Authors:  O Gandrillon; U Schmidt; H Beug; J Samarut
Journal:  EMBO J       Date:  1999-05-17       Impact factor: 11.598

3.  Expression of midkine in the early stage of carcinogenesis in human colorectal cancer.

Authors:  C Ye; M Qi; Q W Fan; K Ito; S Akiyama; Y Kasai; M Matsuyama; T Muramatsu; K Kadomatsu
Journal:  Br J Cancer       Date:  1999-01       Impact factor: 7.640
  3 in total

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