Literature DB >> 7779536

Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation.

H Hida1, C Coudray, J Calop, A Favier.   

Abstract

Adriamycin (25 microM) stimulated NADPH-dependent microsomal lipid peroxidation about fourfold over control values. The tested antioxidants, zinc, superoxide dismutase, vitamin E, and desferrioxamine (Desferal) inhibited Adriamycin-enhanced lipid peroxidation to varying degrees. Others antioxidants, e.g., glutathione, catalase, and selenium, were found to have no effects. Our in vitro studies suggest that adriamycin effect is mediated by a complex oxyradical cascade involving superoxide, hydroxyl radical, and small amounts of iron.

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Year:  1995        PMID： 7779536     DOI： 10.1007/BF02790107

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  13 in total

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Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

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Journal:  Biochem Pharmacol       Date:  1975-04-15       Impact factor: 5.858

4.  Effects of adriamycin on chronic cardiotoxicity in selenium-deficient rats.

Authors:  C Coudray; S Mouhieddine; M J Richard; J Arnaud; J De Leiris; A Favier
Journal:  Basic Res Cardiol       Date:  1992 Mar-Apr       Impact factor: 17.165

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Journal:  Anal Biochem       Date:  1976-11       Impact factor: 3.365

6.  The effects of adriamycin in vitro and in vivo on hepatic microsomal drug-metabolizing enzymes: role of microsomal lipid peroxidation.

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Journal:  Toxicol Appl Pharmacol       Date:  1981-12       Impact factor: 4.219

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Journal:  N Engl J Med       Date:  1981-07-16       Impact factor: 91.245

8.  Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin.

Authors:  E G Mimnaugh; M A Trush; M Bhatnagar; T E Gram
Journal:  Biochem Pharmacol       Date:  1985-03-15       Impact factor: 5.858

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Journal:  Free Radic Biol Med       Date:  1989       Impact factor: 7.376
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  4 in total

1.  Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.

Authors:  Y J Kang; Y Chen; A Yu; M Voss-McCowan; P N Epstein
Journal:  J Clin Invest       Date:  1997-09-15       Impact factor: 14.808

2.  Protective effects of zinc oxide nanoparticles against doxorubicin induced testicular toxicity and DNA damage in male rats.

Authors:  Zeynab Khamis El-Maddawy; Walaa Slouma Hamouda Abd El Naby
Journal:  Toxicol Res (Camb)       Date:  2019-06-15       Impact factor: 3.524

3.  Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium.

Authors:  E Taskin; N Dursun
Journal:  Cytotechnology       Date:  2014-10-18       Impact factor: 2.058

4.  Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats.

Authors:  Otávio Brilhante; Fatima K Okada; Estela Sasso-Cerri; Taiza Stumpp; Sandra M Miraglia
Journal:  Reprod Biol Endocrinol       Date:  2012-09-11       Impact factor: 5.211
  4 in total

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