OBJECTIVE: Our purpose was to determine whether maternal preeclampsia per se has a beneficial effect on neonatal outcome after delivery before 35 weeks. STUDY DESIGN: A matched cohort study design was used. Two hundred twenty-three infants of strictly defined preeclamptic women were matched for gestational age, race, gender, and mode of delivery with infants of normotensive women with preterm labor and delivery. Pregnancies with multiple gestation, premature rupture of membranes, known fetal anomalies, diabetes, or maternal medical disease were excluded. Information was obtained by review of maternal and neonatal charts. Paired categoric and continuous data were compared by McNemar's test and the Wilcoxon signed-rank test, respectively. RESULTS: There was no difference in the incidence of neonatal death (4.5% vs 4.5%, p = 0.82), respiratory distress syndrome (22.0% vs 22.0%, p = 0.88), grades 3 and 4 intraventricular hemorrhage (2.2% vs 2.2%, p = 0.72), grades 2 and 3 necrotizing enterocolitis (5.8% vs 4.0%, p = 0.48), and culture-proved sepsis (9.0% vs 9.0%, p = 0.85). Results were similar when analysis was limited to infants born at < or = 32 weeks, infants born to mothers with severe preeclampsia, and infants with intrauterine growth restriction. CONCLUSION: Maternal preeclampsia per se does not have a beneficial effect on the postnatal course of infants born at 24 to 35 weeks' gestation.
OBJECTIVE: Our purpose was to determine whether maternal preeclampsia per se has a beneficial effect on neonatal outcome after delivery before 35 weeks. STUDY DESIGN: A matched cohort study design was used. Two hundred twenty-three infants of strictly defined preeclamptic women were matched for gestational age, race, gender, and mode of delivery with infants of normotensive women with preterm labor and delivery. Pregnancies with multiple gestation, premature rupture of membranes, known fetal anomalies, diabetes, or maternal medical disease were excluded. Information was obtained by review of maternal and neonatal charts. Paired categoric and continuous data were compared by McNemar's test and the Wilcoxon signed-rank test, respectively. RESULTS: There was no difference in the incidence of neonatal death (4.5% vs 4.5%, p = 0.82), respiratory distress syndrome (22.0% vs 22.0%, p = 0.88), grades 3 and 4 intraventricular hemorrhage (2.2% vs 2.2%, p = 0.72), grades 2 and 3 necrotizing enterocolitis (5.8% vs 4.0%, p = 0.48), and culture-proved sepsis (9.0% vs 9.0%, p = 0.85). Results were similar when analysis was limited to infants born at < or = 32 weeks, infants born to mothers with severe preeclampsia, and infants with intrauterine growth restriction. CONCLUSION: Maternal preeclampsia per se does not have a beneficial effect on the postnatal course of infants born at 24 to 35 weeks' gestation.
Authors: Edi Vaisbuch; Janice E Whitty; Sonia S Hassan; Roberto Romero; Juan Pedro Kusanovic; David B Cotton; Yoram Sorokin; S Ananth Karumanchi Journal: Am J Obstet Gynecol Date: 2010-11-09 Impact factor: 8.661
Authors: Arthur M Baker; Sina Haeri; Carlos A Camargo; Janice A Espinola; Alison M Stuebe Journal: J Clin Endocrinol Metab Date: 2010-08-18 Impact factor: 5.958
Authors: Sarosh Rana; Michele R Hacker; Anna Merport Modest; Saira Salahuddin; Kee-Hak Lim; Stefan Verlohren; Frank H Perschel; S Ananth Karumanchi Journal: Hypertension Date: 2012-07-02 Impact factor: 10.190
Authors: Sarosh Rana; Camille E Powe; Saira Salahuddin; Stefan Verlohren; Frank H Perschel; Richard J Levine; Kee-Hak Lim; Julia B Wenger; Ravi Thadhani; S Ananth Karumanchi Journal: Circulation Date: 2012-01-18 Impact factor: 29.690
Authors: Alice Wang; Alexander M Holston; Kai F Yu; Jun Zhang; Mourad Toporsian; S Ananth Karumanchi; Richard J Levine Journal: J Matern Fetal Neonatal Med Date: 2011-12-13
Authors: Glenn E Palomaki; James E Haddow; Hamish R M Haddow; Saira Salahuddin; Carl Geahchan; Ana Sofia Cerdeira; Stefan Verlohren; Frank H Perschel; Gary Horowitz; Ravi Thadhani; S Ananth Karumanchi; Sarosh Rana Journal: Prenat Diagn Date: 2015-02-04 Impact factor: 3.050