Literature DB >> 7778304

Minimum origin requirements for linear duplex AAV DNA replication in vitro.

P Ward1, K I Berns.   

Abstract

We have investigated the minimal requirements for a functional origin of DNA replication in an in vitro assay which requires the adeno-associated virus (AAV) Rep 68/78 protein. When a linear duplex template was used, initiation of one round of DNA replication was achieved when nucleotides 1-56 of the AAV inverted terminal repeat (in the flop orientation) were present at the terminus of the template. A terminal resolution site was not required. Deletion of an additional 11 nucleotides from the terminal repeat blocked the reaction.

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Year:  1995        PMID： 7778304     DOI： 10.1006/viro.1995.1306

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  16 in total

1.  An adeno-associated virus (AAV) initiator protein, Rep78, catalyzes the cleavage and ligation of single-stranded AAV ori DNA.

Authors:  R H Smith; R M Kotin
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

2.  Native molecular state of adeno-associated viral vectors revealed by single-molecule sequencing.

Authors:  Philipp Kapranov; Lingxia Chen; Debra Dederich; Biao Dong; Jie He; Kathleen E Steinmann; Andrea R Moore; John F Thompson; Patrice M Milos; Weidong Xiao
Journal:  Hum Gene Ther       Date:  2011-10-04       Impact factor: 5.695

3.  The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity.

Authors:  R H Smith; R M Kotin
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

4.  Adeno-associated virus type 2 DNA replication in vivo: mutation analyses of the D sequence in viral inverted terminal repeats.

Authors:  X S Wang; K Qing; S Ponnazhagan; A Srivastava
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

5.  The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences.

Authors:  R H Smith; A J Spano; R M Kotin
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

6.  Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins.

Authors:  Daniel L Glauser; Okay Saydam; N Alexander Balsiger; Irma Heid; R Michael Linden; Mathias Ackermann; Cornel Fraefel
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

7.  The cellular TATA binding protein is required for rep-dependent replication of a minimal adeno-associated virus type 2 p5 element.

Authors:  Achille François; Mickaël Guilbaud; Rafi Awedikian; Gilliane Chadeuf; Philippe Moullier; Anna Salvetti
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

8.  Adeno-associated virus site-specific integration and AAVS1 disruption.

Authors:  Henry Hamilton; Janette Gomos; Kenneth I Berns; Erik Falck-Pedersen
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

9.  Herpes simplex virus type 1/adeno-associated virus hybrid vectors.

Authors:  Anna Paula de Oliveira; Cornel Fraefel
Journal:  Open Virol J       Date:  2010-06-18

10.  Spatial and temporal organization of adeno-associated virus DNA replication in live cells.

Authors:  Cornel Fraefel; Anne Greet Bittermann; Hansruedi Büeler; Irma Heid; Thomas Bächi; Mathias Ackermann
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103
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