| Literature DB >> 7778148 |
S Krishna1, W Supanaranond, S Pukrittayakamee, F ter Kuile, Y Supputamangkol, K Attatamsoonthorn, M Ruprah, N J White.
Abstract
The effects of quinine and paracetamol on fever were studied in 21 adult patients with acute uncomplicated falciparum malaria. Quinine alone (n = 7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n = 7) or 2 h before quinine (n = 7) reduced temperature by a mean of 2.1 degrees C (standard deviation [SD] 0.95) and 2.1 degrees C (SD 0.79) respectively. A temperature reduction of 1 degree C was associated with a mean decrement of 9.7 beats/min (SD 3.3) in the pulse rate. Quinine does not possess useful antipyretic activity.Entities:
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Year: 1995 PMID： 7778148 DOI： 10.1016/0035-9203(95)90494-8
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184