| Literature DB >> 7775984 |
Y Kashiwada1, M Nishizawa, T Yamagishi, T Tanaka, G Nonaka, L M Cosentino, J V Snider, K Lee.
Abstract
Monosodium and monopotassium salts [2-4] of isomeric caffeic acid tetramers were isolated from Arnebia euchroma as anti-HIV agents. Mixtures of dipotassium and disodium salts [1] of a caffeic acid tetramer and dipotassium and potassium-sodium salts [5] of a caffeic acid tetramer glucoside were also isolated from the active fraction. The structures of 1-5 were characterized by chemical and spectral evidence. Compounds 2-4 demonstrated potent anti-HIV activity with EC50 values of 2.8, 4.0, and 1.5 micrograms/ml, respectively. Treatment of 1-4 with dilute HCl yielded known caffeic acid tetramers [8 and 9], which were found to be less active, indicating the importance of the sodium and potassium salts to the enhanced anti-HIV activity.Entities:
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Year: 1995 PMID： 7775984 DOI： 10.1021/np50117a007
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050