Clozapine overdose, a case report.

Clozapine, an atypical antipsychotic agent with few of the extrapyramidal side effects of other antipsychotic agents, was approved for use in the United States in 1989. Because of drug-induced agranulocytosis, it is dispensed only under rigid guidelines. Overdose has been rare. Presented here is a case of clozapine overdose treated successfully with supportive care in which agranulocytosis did not develop.