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Literature DB >> 7773587

Epstein-Barr virus immortalizing genes.

Abstract

Epstein-Barr virus (EBV) is linked to several types of human cancer and immortalizes human B cells very efficiently; at least six viral genes are required for this. The mechanism by which EBV immortalizes cells is particularly interesting because its immortalization genes are not obvious homologues of those of other DNA tumour viruses.

Entities: Disease Species

Mesh：

Year: 1995 PMID： 7773587 DOI： 10.1016/s0966-842x(00)88891-5

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

32 in total

1. Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.

Authors: L C Spender; E J Cannell; M Hollyoake; B Wensing; J M Gawn; M Brimmell; G Packham; P J Farrell
Journal: J Virol Date: 1999-06 Impact factor: 5.103

2. Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP.

Authors: B Wensing; A Stühler; P Jenkins; M Hollyoake; C E Karstegl; P J Farrell
Journal: J Virol Date: 2001-07 Impact factor: 5.103

3. LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2.

Authors: A Kieser; C Kaiser; W Hammerschmidt
Journal: EMBO J Date: 1999-05-04 Impact factor: 11.598

4. TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40.

Authors: Aristides G Eliopoulos; Elyse R Waites; Sarah M S Blake; Clare Davies; Paul Murray; Lawrence S Young
Journal: J Virol Date: 2003-01 Impact factor: 5.103

Epstein-Barr virus immortalizing genes.

1. Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.

2. Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP.

3. LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2.

4. TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40.

5. Multiple functions within the Epstein-Barr virus EBNA-3A protein.

6. B-lymphoblastoid cell lines from cancer patients.

Review 7. The complexity of the Epstein-Barr virus infection in humans.

Review 8. Experimental investigation of herpes simplex virus latency.

9. Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins.

10. CTCF prevents the epigenetic drift of EBV latency promoter Qp.