Literature DB >> 7773573

Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.

R W Mahley1, B P Nathan, S Bellosta, R E Pitas.   

Abstract

Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.

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Year:  1995        PMID： 7773573     DOI： 10.1097/00041433-199504000-00005

Source DB:  PubMed          Journal:  Curr Opin Lipidol        ISSN： 0957-9672            Impact factor:   4.776


  10 in total

1.  Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

Authors:  M Buttini; M Orth; S Bellosta; H Akeefe; R E Pitas; T Wyss-Coray; L Mucke; R W Mahley
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

2.  Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo.

Authors:  C N Bassett; M D Neely; K R Sidell; W R Markesbery; L L Swift; T J Montine
Journal:  Lipids       Date:  1999-12       Impact factor: 1.880

3.  Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

Authors:  K S Montine; S J Olson; V Amarnath; W O Whetsell; D G Graham; T J Montine
Journal:  Am J Pathol       Date:  1997-02       Impact factor: 4.307

4.  Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content.

Authors:  M Racchi; R Baetta; N Salvietti; P Ianna; G Franceschini; R Paoletti; R Fumagalli; S Govoni; M Trabucchi; M Soma
Journal:  Biochem J       Date:  1997-03-15       Impact factor: 3.857

5.  Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E.

Authors:  Arnaud Leroy; Isabelle Landrieu; Isabelle Huvent; Dominique Legrand; Bernadette Codeville; Jean-Michel Wieruszeski; Guy Lippens
Journal:  J Biol Chem       Date:  2010-08-02       Impact factor: 5.157

6.  The magnitude of brain lipid peroxidation correlates with the extent of degeneration but not with density of neuritic plaques or neurofibrillary tangles or with APOE genotype in Alzheimer's disease patients.

Authors:  T J Montine; W R Markesbery; W Zackert; S C Sanchez; L J Roberts; J D Morrow
Journal:  Am J Pathol       Date:  1999-09       Impact factor: 4.307

7.  HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide.

Authors:  Brian Giunta; Yuyan Zhou; Huayan Hou; Elona Rrapo; Francisco Fernandez; Jun Tan
Journal:  Int J Clin Exp Pathol       Date:  2008-01-01

Review 8.  Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.

Authors:  Yadong Huang; Karl H Weisgraber; Lennart Mucke; Robert W Mahley
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444

9.  Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism.

Authors:  Ruth Frikke-Schmidt; Charles F Sing; Børge G Nordestgaard; Anne Tybjaerg-Hansen
Journal:  Hum Genet       Date:  2004-09       Impact factor: 4.132

10.  Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture.

Authors:  Aseem Hussain; Minh Luong; Apryl Pooley; Britto P Nathan
Journal:  J Biomed Sci       Date:  2013-07-12       Impact factor: 8.410
  10 in total

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