Literature DB >> 7773289

A 2D crossover-based map of the human X chromosome as a model for map integration.

P R Fain1, E N Kort, P F Chance, K Nguyen, D F Redd, M J Econs, D F Barker.   

Abstract

We have constructed a two-dimensional map of 243 markers on the X chromosome. The average distance between markers ordered by two recombinants is 5.4 centiMorgans (cM), which is reduced to 3.2 cM using a less stringent criterion of one recombinant. Map resolution is enhanced by replacing the usual reference marker format with a 2D format, and the two-recombinant rule is more conservative than the lod 3.0 criterion for order. Taken together, crossover mapping and the 2D format produces maps with greater reliability and higher resolution than maps constructed using currently accepted standards. This first high-density crossover-based map of an entire human chromosome provides a model for integrating physical and genetic maps.

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Year:  1995        PMID： 7773289     DOI： 10.1038/ng0395-261

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  9 in total

1.  Fried syndrome is a distinct X linked mental retardation syndrome mapping to Xp22.

Authors:  L Strain; A F Wright; D T Bonthron
Journal:  J Med Genet       Date:  1997-07       Impact factor: 6.318

2.  Linkage analysis in Rett syndrome families suggests that there may be a critical region at Xq28.

Authors:  T Webb; A Clarke; F Hanefeld; J L Pereira; L Rosenbloom; C G Woods
Journal:  J Med Genet       Date:  1998-12       Impact factor: 6.318

3.  Heritability of X chromosome--inactivation phenotype in a large family.

Authors:  A K Naumova; R M Plenge; L M Bird; M Leppert; K Morgan; H F Willard; C Sapienza
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

4.  Parental origin-dependent, male offspring-specific transmission-ratio distortion at loci on the human X chromosome.

Authors:  A K Naumova; M Leppert; D F Barker; K Morgan; C Sapienza
Journal:  Am J Hum Genet       Date:  1998-06       Impact factor: 11.025

5.  Genetic localisation of mental retardation with spastic diplegia to the pericentromeric region of the X chromosome: X inactivation in female carriers.

Authors:  F Martínez; M Tomás; J M Millán; A Fernández; F Palau; F Prieto
Journal:  J Med Genet       Date:  1998-04       Impact factor: 6.318

6.  Familial skewed X inactivation: a molecular trait associated with high spontaneous-abortion rate maps to Xq28.

Authors:  E Pegoraro; J Whitaker; P Mowery-Rushton; U Surti; M Lanasa; E P Hoffman
Journal:  Am J Hum Genet       Date:  1997-07       Impact factor: 11.025

7.  Discordant segregation of Xq28 markers and a mutation in the L1 gene in a family with X linked hydrocephalus.

Authors:  M Jouet; L Strain; D Bonthron; S Kenwrick
Journal:  J Med Genet       Date:  1996-03       Impact factor: 6.318

8.  Definitive evidence for an autosomal recessive form of hypohidrotic ectodermal dysplasia clinically indistinguishable from the more common X-linked disorder.

Authors:  F Munoz; G Lestringant; V Sybert; M Frydman; A Alswaini; P M Frossard; R Jorgenson; J Zonana
Journal:  Am J Hum Genet       Date:  1997-07       Impact factor: 11.025

9.  The locus for a novel syndromic form of neuronal intestinal pseudoobstruction maps to Xq28.

Authors:  A Auricchio; V Brancolini; G Casari; P J Milla; V V Smith; M Devoto; A Ballabio
Journal:  Am J Hum Genet       Date:  1996-04       Impact factor: 11.025
  9 in total

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