BACKGROUND: Detection of hepatitis B surface antigen (HBsAg) in recently vaccinated adults has not previously been reported. Transient detectable HBsAg has been observed in newborn infants immunized with a recombinant hepatitis B vaccine. STUDY DESIGN AND METHODS: Over a 1-year period, eight HBsAg-positive blood donors mentioned during donor notification that they had been vaccinated for hepatitis B virus 1 to 3 days before donation. Follow-up tests for HBsAg, antibodies to HBsAg, and antibodies to hepatitis B core antigen were performed 3 to 37 weeks after immunization. Four months later, a group of 19 donors who were coworkers received hepatitis B vaccination and then donated blood the next day. The coworkers were observed for duration of antigenemia. RESULTS: A total of nine cases of transient, confirmed (neutralizable) antigenemia occurred in healthy individuals who donated blood 1 to 3 days following vaccination with a recombinant hepatitis B vaccine. Follow-up testing showed no evidence of infection by hepatitis B virus. One (5.3%) of 19 blood donors vaccinated as a group had antigenemia at Day 1 but not on Days 2 and 3 following immunization. CONCLUSION: Individuals recently vaccinated for hepatitis B may test positive for HBsAg and become permanently disqualified as blood donors. Therefore, blood collection centers should consider temporary deferral of potential donors who recently received hepatitis B vaccine.
BACKGROUND: Detection of hepatitis B surface antigen (HBsAg) in recently vaccinated adults has not previously been reported. Transient detectable HBsAg has been observed in newborn infants immunized with a recombinant hepatitis B vaccine. STUDY DESIGN AND METHODS: Over a 1-year period, eight HBsAg-positive blood donors mentioned during donor notification that they had been vaccinated for hepatitis B virus 1 to 3 days before donation. Follow-up tests for HBsAg, antibodies to HBsAg, and antibodies to hepatitis B core antigen were performed 3 to 37 weeks after immunization. Four months later, a group of 19 donors who were coworkers received hepatitis B vaccination and then donated blood the next day. The coworkers were observed for duration of antigenemia. RESULTS: A total of nine cases of transient, confirmed (neutralizable) antigenemia occurred in healthy individuals who donated blood 1 to 3 days following vaccination with a recombinant hepatitis B vaccine. Follow-up testing showed no evidence of infection by hepatitis B virus. One (5.3%) of 19 blood donors vaccinated as a group had antigenemia at Day 1 but not on Days 2 and 3 following immunization. CONCLUSION: Individuals recently vaccinated for hepatitis B may test positive for HBsAg and become permanently disqualified as blood donors. Therefore, blood collection centers should consider temporary deferral of potential donors who recently received hepatitis B vaccine.
Authors: F J van Deursen; K Hino; D Wyatt; P Molyneaux; P Yates; L A Wallace; B C Dow; W F Carman Journal: J Clin Pathol Date: 1998-02 Impact factor: 3.411
Authors: Kathryn E Stephenson; Chen Sabrina Tan; Stephen R Walsh; Andrew Hale; Jessica L Ansel; Diane G Kanjilal; Kate Jaegle; Lauren Peter; Erica N Borducchi; Joseph P Nkolola; Tatenda Makoni; Rachel Fogel; Connor Bradshaw; Anna Tyler; Edward Moseley; Abishek Chandrashekar; Katherine E Yanosick; Michael S Seaman; Kenneth H Eckels; Rafael A De La Barrera; Jason Thompson; Peter Dawson; Stephen J Thomas; Nelson L Michael; Kayvon Modjarrad; Dan H Barouch Journal: Lancet Infect Dis Date: 2020-05-06 Impact factor: 25.071
Authors: Cristina Corsini Campioli; Zerelda Esquer Garrigos; Mariam Assi; John Raymond Go; Raymund R Razonable; Elena Beam; Joseph Yao; Nathan W Cummins Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2021-01-24