H J Feldmann1, M H Seegenschmiedt, M Molls. 1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der TU München.
Abstract
PURPOSE: Combined hyperthermia and radiation therapy has been reported to yield higher complete and durable responses than radiotherapy alone in superficial tumors. In deep seated tumors the effect of the combined treatment is still under research. METHODS: The literature and own clinical data are reviewed with regard to biological and physical fundamentals and clinical results. RESULTS: Clinical phase I to II studies have applied regional hyperthermia in the abdomen, the pelvic region and the extremities. Usually primary advanced, persistent or local recurrent and metastatic tumors were selected for treatment either due to poor response to conventional therapy or for effective palliation. The clinical data are presented concerning the following topics: invasive thermometry, temperature parameter in tumor and normal tissue, toxicity, tumor response, treatment planning, clinical trials and prognostic factors. Clinical results of thermoradiotherapy for advanced or recurrent rectal cancer, cervical cancer and soft tissue sarcomas are reviewed in detail. In addition, the prognostic relevance of temperature parameters and physiological conditions such as global tumor perfusion are discussed. CONCLUSION: Clinical issues of optimization of regional thermoradiotherapy are: improvement of hyperthermia technique, analysis of biological effects and mechanisms involved in temperature elevation, selection of appropriate study concepts for specific tumor sites. Part I has covered biological and technical fundamentals of clinical hyperthermia and has been published in Strahlenther. Onkol. 168 (1992), 183-190. Part II has covered clinical fundamentals and results in superficial tumors of clinical hyperthermia and has been published in Strahlenther.
PURPOSE: Combined hyperthermia and radiation therapy has been reported to yield higher complete and durable responses than radiotherapy alone in superficial tumors. In deep seated tumors the effect of the combined treatment is still under research. METHODS: The literature and own clinical data are reviewed with regard to biological and physical fundamentals and clinical results. RESULTS: Clinical phase I to II studies have applied regional hyperthermia in the abdomen, the pelvic region and the extremities. Usually primary advanced, persistent or local recurrent and metastatic tumors were selected for treatment either due to poor response to conventional therapy or for effective palliation. The clinical data are presented concerning the following topics: invasive thermometry, temperature parameter in tumor and normal tissue, toxicity, tumor response, treatment planning, clinical trials and prognostic factors. Clinical results of thermoradiotherapy for advanced or recurrent rectal cancer, cervical cancer and soft tissue sarcomas are reviewed in detail. In addition, the prognostic relevance of temperature parameters and physiological conditions such as global tumor perfusion are discussed. CONCLUSION: Clinical issues of optimization of regional thermoradiotherapy are: improvement of hyperthermia technique, analysis of biological effects and mechanisms involved in temperature elevation, selection of appropriate study concepts for specific tumor sites. Part I has covered biological and technical fundamentals of clinical hyperthermia and has been published in Strahlenther. Onkol. 168 (1992), 183-190. Part II has covered clinical fundamentals and results in superficial tumors of clinical hyperthermia and has been published in Strahlenther.
Authors: R Paul; R Hofmann; J U Schwarzer; R Stepan; H J Feldmann; P Kneschaurek; M Molls; R Hartung Journal: World J Urol Date: 1997 Impact factor: 4.226