UNLABELLED: Myocardial sympathetic nervous function has been evaluated with 123I-metaiodobenzylguanidine (MIBG) imaging in various cardiac diseases. Heterogeneous distribution of this tracer has been reported. This study was undertaken to assess whether such heterogeneity is related to age and gender. METHODS: Twenty-nine subjects (18 men, 11 women; age range, 21 to 79 yr; mean age 42 +/- 17 yr) with no cardiac disorders were studied. Early (15 min) and late (3-4 hr) planar images were taken, and SPECT images were also obtained 3-4 hr after MIBG injection (111 MBq). The mean counts of the whole heart, mediastinum and the anterior and inferior regions of the heart were obtained to calculate heart-to-mediastinum count ratios, myocardial washout rates and the inferior-to-anterior wall count ratio. On a bull's-eye map of the SPECT images, the left ventricular myocardium was divided into nine sectors to calculate the inferior-to-anterior wall count ratio. RESULTS: There were no significant differences in the heart-to-mediastinum count ratio based on age or gender, but there was a significant inverse correlation between the inferior-to-anterior wall count ratio and age (r = -0.51 on late planar images and r = -0.69 on SPECT; p < 0.01 and p < 0.001, respectively). This correlation was valid in men (r = -0.74 and -0.83, respectively; both p < 0.001), but not in women (r = -0.25 and -0.34, respectively; p = ns). CONCLUSION: Inferior wall uptake of MIBG decreased with age in individuals without cardiac diseases, especially men. Such age- and gender-related heterogeneity should be considered in the interpretation of MIBG images.
UNLABELLED: Myocardial sympathetic nervous function has been evaluated with 123I-metaiodobenzylguanidine (MIBG) imaging in various cardiac diseases. Heterogeneous distribution of this tracer has been reported. This study was undertaken to assess whether such heterogeneity is related to age and gender. METHODS: Twenty-nine subjects (18 men, 11 women; age range, 21 to 79 yr; mean age 42 +/- 17 yr) with no cardiac disorders were studied. Early (15 min) and late (3-4 hr) planar images were taken, and SPECT images were also obtained 3-4 hr after MIBG injection (111 MBq). The mean counts of the whole heart, mediastinum and the anterior and inferior regions of the heart were obtained to calculate heart-to-mediastinum count ratios, myocardial washout rates and the inferior-to-anterior wall count ratio. On a bull's-eye map of the SPECT images, the left ventricular myocardium was divided into nine sectors to calculate the inferior-to-anterior wall count ratio. RESULTS: There were no significant differences in the heart-to-mediastinum count ratio based on age or gender, but there was a significant inverse correlation between the inferior-to-anterior wall count ratio and age (r = -0.51 on late planar images and r = -0.69 on SPECT; p < 0.01 and p < 0.001, respectively). This correlation was valid in men (r = -0.74 and -0.83, respectively; both p < 0.001), but not in women (r = -0.25 and -0.34, respectively; p = ns). CONCLUSION: Inferior wall uptake of MIBG decreased with age in individuals without cardiac diseases, especially men. Such age- and gender-related heterogeneity should be considered in the interpretation of MIBG images.
Authors: Maureen M Henneman; Frank M Bengel; Ernst E van der Wall; Juhani Knuuti; Jeroen J Bax Journal: J Nucl Cardiol Date: 2008-04-16 Impact factor: 5.952
Authors: J W Ha; J D Lee; Y Jang; N Chung; J Kwan; S J Rim; Y J Lee; W H Shim; S Y Cho; S S Kim Journal: J Nucl Cardiol Date: 1998 Nov-Dec Impact factor: 5.952
Authors: K Hamada; M Hirayama; H Watanabe; R Kobayashi; H Ito; T Ieda; Y Koike; G Sobue Journal: J Neurol Neurosurg Psychiatry Date: 2003-04 Impact factor: 10.154
Authors: Arnold F Jacobson; Ji Chen; Liudmilla Verdes; Russell D Folks; Daya N Manatunga; Ernest V Garcia Journal: J Nucl Cardiol Date: 2013-03-13 Impact factor: 5.952