Literature DB >> 7768878

A gratuitous inducer of cat-86, amicetin, inhibits bacterial peptidyl transferase.

Z Gu1, P S Lovett.   

Abstract

Expression of the chloramphenicol resistance gene cat-86 is regulated by translation attenuation. Among the three ribosomally targeted antibiotics that can induce the gene, only amicetin has an unknown mode of action. Here we demonstrate that the nucleoside antibiotic amicetin is an inhibitor of bacterial peptidyl transferase. Thus, the three inducers of cat-86, chloramphenicol, erythromycin, and amicetin, interact with the peptidyl transferase region of bacterial ribosomes.

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Year:  1995        PMID： 7768878      PMCID： PMC177074          DOI： 10.1128/jb.177.12.3616-3618.1995

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

1.  Sequence analysis of the inducible chloramphenicol resistance determinant in the Tn1696 integron suggests regulation by translational attenuation.

Authors:  H W Stokes; R M Hall
Journal:  Plasmid       Date:  1991-07       Impact factor: 3.466

2.  Subunit localization studies of antibiotic inhibitors of protein synthesis.

Authors:  F N Chang; C Siddhikol; B Weisblum
Journal:  Biochim Biophys Acta       Date:  1969-08-20

3.  Erythromycin induces expression of the chloramphenicol acetyltransferase gene cat-86.

Authors:  E J Rogers; P S Lovett
Journal:  J Bacteriol       Date:  1990-08       Impact factor: 3.490

4.  Properties of a pentapeptide inhibitor of peptidyltransferase that is essential for cat gene regulation by translation attenuation.

Authors:  Z Gu; R Harrod; E J Rogers; P S Lovett
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

Review 5.  Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics.

Authors:  D Dubnau
Journal:  CRC Crit Rev Biochem       Date:  1984

6.  Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotide.

Authors:  R E Monro; K A Marcker
Journal:  J Mol Biol       Date:  1967-04-28       Impact factor: 5.469

7.  Ribosome-catalysed peptidyl transfer: effects of some inhibitors of protein synthesis.

Authors:  R E Monro; D Vazquez
Journal:  J Mol Biol       Date:  1967-08-28       Impact factor: 5.469

8.  Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol-resistance genes.

Authors:  Z Gu; R Harrod; E J Rogers; P S Lovett
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

9.  Posttranscriptional regulation of the inducible nonenzymatic chloramphenicol resistance determinant of IncP plasmid R26.

Authors:  C J Dorman; T J Foster
Journal:  J Bacteriol       Date:  1985-01       Impact factor: 3.490

10.  A conserved secondary structural motif in 23S rRNA defines the site of interaction of amicetin, a universal inhibitor of peptide bond formation.

Authors:  I G Leviev; C Rodriguez-Fonseca; H Phan; R A Garrett; G Heilek; H F Noller; A S Mankin
Journal:  EMBO J       Date:  1994-04-01       Impact factor: 11.598
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  2 in total

Review 1.  Ribosome regulation by the nascent peptide.

Authors:  P S Lovett; E J Rogers
Journal:  Microbiol Rev       Date:  1996-06

2.  Peptide inhibitors of peptidyltransferase alter the conformation of domains IV and V of large subunit rRNA: a model for nascent peptide control of translation.

Authors:  R Harrod; P S Lovett
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-12       Impact factor: 11.205
  2 in total

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